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1.WO/1987/004726PROCESS FOR PURIFYING RECOMBINANT PROTEINS, AND PRODUCTS THEREOF

WO - 13.08.1987

国际分类 C07K 1/113 申请号 PCT/US1987/000223 申请人 CAMBRIDGE BIOSCIENCE CORPORATION 发明人 HUNG, Chung-Ho

Process for recovering recombinant protein from refractile inclusion bodies of microorganisms which comprises disrupting cells, recovering refractile bodies containing recombinant protein, solubilizing the refractile bodies with a denaturant, protecting sulfhydryl groups of recombinant proteins, converting cationic amino groups of recombinant proteins to anionic carboxylic acid by derivatization with organic cyclic acid anhydrides, and recovering recombinant protein derivatives. The present invention also relates to the production of solid supports coated with recombinant protein recovered by the process of the invention, and the use of said devices for the detection and quantification of antibodies to said recombinant proteins in body fluids.

2.WO/1986/006126BLOCK MADE OF HYPER-PRESSED DOUBLE COMPRESSED AND COLD-STABILIZED EARTH FOR JOINTLESS CONSTRUCTION

WO - 23.10.1986

国际分类 E04C 1/40 申请号 PCT/BE1986/000012 申请人 TADDEI, Serge 发明人 TADDEI, Serge

Self-nesting hollow block made of hyper-pressed double compressed cold-stabilized earth, enabling the construction of jointless walls and of which the stability is provided by the vertical injection at its centre (1) and on both its extremities (2) and the horizontal injection (5-6) of liquid earth-cement mortar. Due to its multiple shapes - four -, said block enables the construction of a house which is entirely made of earth without using formwork, irons, stays or other materials, eliminates rough casting outside and inside, thereby resulting in important savings in cement and labour.

3.WO/1985/004122PROCESS FOR RECOVERING CRUDE OIL OR REFINED PRODUCTS FROM SEDIMENTED, FROM SLUDGY AND THICKENED TO COMPACT CRUDE OIL OR REFINED PRODUCTS, AS WELL AS PLANT FOR IMPLEMENTING SUCH PROCESS

WO - 26.09.1985

国际分类 B01F 5/02 申请号 PCT/EP1985/000090 申请人 FIPROSA HOLDING 发明人 MATTER, Rolf

The process for the recovery of residue-mixed crude oil or refinery products derived from crude oil, these residues being essentially comprised of sludgy, thickened crude oil deposited by sedimentation or refinery products extracted from crude oil and deposited by sedimentation in storage or transport containers to form a more or less compact deposition, is characterized in that the residues containing the oil or other refinery products are resuspended or redissolved in the liquid phase by means of the hydrodynamic energy of liquefaction agents, such as crude oil or fractions thereof, which are mainly chemically affined and pressure-reduced in the remaining liquid phase or directly in the residues, respectively in the sediment. The plant provided for implementing such process comprises at least one liquefaction lance (13) which may be introduced into a container (9) with the sediment or the sedimentary material to be released and comprising at least one nozzle (12) arranged thereon, as well as one or a plurality of conduits conducting to the nozzle or nozzles for pumping the chemically affined liquefaction agents.

4.WO/1987/002696AMMONIA TREATMENT PLANT AND METHOD

WO - 07.05.1987

国际分类 B01D 53/14 申请号 PCT/FR1986/000356 申请人 L'AIR LIQUIDE, SOCIETE ANONYME POUR L'ETUDE ET L'E 发明人 BRUGEROLLE, Jean-Renaud

According to the disclosed method, the ammonia is removed from a gas effluent of the washing treatment by means of a liquid which is essentially comprised of water, the washing liquid is then regenerated by backflow distillation of the gas to be treated, whereafter at least the major part of the regenerated washing liquid is recycled by heat exchange with the washing liquid to be regenerated. Application for the production of CO₂ by treating fumes with ammonia.

5.WO/1996/004350FOAMED DRILLING FLUIDS, THEIR PROCESS FOR PREPARATION AND THE CORRESPONDING DRILLING METHOD

WO - 15.02.1996

国际分类 C09K 8/38 申请号 PCT/EP1995/003102 申请人 SOFITECH N.V. 发明人 WILLIAMSON, Don

The present invention is directed to an aqueous foamed drilling fluid for drilling well bores into a subterranean formation, comprising water, at least one clay and at least one foaming agent. According to the invention, it further comprises at least one metal hydroxide. The invention further relates to a method for preparing said foamed drilling fluid.

6.WO/1985/005159HIGH-PRESSURE FERROFLUID SEAL APPARATUS

WO - 21.11.1985

国际分类 F16J 15/43 申请号 PCT/US1985/000810 申请人 FERROFLUIDICS CORPORATION 发明人 GOWDA, Hanumaiah, L.

A high-pressure rotary seal apparatus with a radially-polarized permanent magnet (26), which seal apparatus comprises: a housing (12); a magnetically-permeable shaft (18) to be sealed extending through the housing (12), the shaft (18) characterized by a plurality of separate grooves (22) or stages on the shaft, a radially-polarized permanent magnet (26) extending about the shaft (18), at least one pole piece (28) adjacent to and in a magnetic flux relationship with the radially-polarized permanent magnet (26) and extending about the shaft (18), one polarized end of the polarized magnet (26) and one end of the pole piece (28) extending into a close, noncontacting relationship with the grooves (22) on the surface of the shaft (18) to form a plurality of separate radial gaps; ferrofluid (34) disposed in the radial gaps to define a plurality of separate, spaced-apart ferrofluid O-ring seals (34) about the surface of the shaft (18); and a generally cylindrical, magnetically-permeable keeper element (24) extending about the other polarized end of the magnet (26) and the other end of the pole piece (28) in order to provide a magnetic flux circuit which extends between the radially-polarized magnet (26), the keeper element (24), the shaft (8), and the ferrofluid (34) in the radial gaps.

7.WO/1987/004728PEPTIDES FOR THE DIAGNOSIS OF HTLV-III ANTIBODIES, THEIR PREPARATION AND USE

WO - 13.08.1987

国际分类 C07K 1/113 申请号 PCT/US1987/000225 申请人 CAMBRIDGE BIOSCIENCE CORPORATION 发明人 BELTZ, Gerald, A.

Certain peptide fragments of the human T-cell leukemia (lymphotropic) virus (HTLV-III) are particularly immunoreactive to HTLV-III antibodies, and can therefore be applied to immunodiagnostic tests for the detection of antibodies to HTLV-III.

8.WO/1994/018970COLD/SINUS PREPARATION CONSISTING OF PHENINDAMINE TARTARATE WITH OR WITHOUT THERAPEUTIC AGENTS

WO - 01.09.1994

国际分类 A61K 9/14 申请号 PCT/US1994/000378 申请人 WARNER-LAMBERT COMPANY 发明人 LECH, Stanley

The present invention is an improved pharmaceutical composition useful in the treatment of colds, sinus and allergies comprising an unstable antihistamine such as phenindamine that is stabilized in a non-aqueous, inert carrier system. More specifically, the phenindamine is stabilized in a mineral oil/fumed silica particle matrix which so stabilizes the compound that additional, otherwise reactive drugs such as analgesics, decongestants and expectorants can be incorporated for a more effective, multi-system formula.

9.WO/1998/029638DEEPWATER RISER SYSTEM

WO - 09.07.1998

国际分类 E21B 17/01 申请号 PCT/EP1997/007342 申请人 SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. 发明人 BALINT, Stephen, William

A deepwater riser assembly (10) for application at an offshore platform comprising: a riser (20) connecting subsea equipment to a surface wellhead; a buoyancy can assembly (30), comprising: an open-ended buoyancy can tube (32) surrounding the upper part end of the riser; a seal (62) arranged in an upper part of the buoyancy can tube so as to effectively close the annulus between the riser and the buoyancy can tube; and a load transfer connection (64B) between the buoyancy can tube and the riser; a pressure charging system (72) communicating with said annulus between the riser and the buoyancy can tube at a location below the seal.

10.WO/1988/004324PULMONARY HYDROPHOBIC SURFACTANT-ASSOCIATED PROTEINS

WO - 16.06.1988

国际分类 A61K 35/42 申请号 PCT/US1987/003180 申请人 ABBOTT LABORATORIES 发明人 WHITSETT, Jeffrey, A.

Novel, isolated, substantially pure, hydrophobic surfactant-associated proteins of 4,000-7,000 dalton simple molecular weight, SAP(Val) and SAP(Phe); multimers thereof, and substitution, addition and deletion analogs and fragments thereof. When SAP(Val) and/or SAP(Phe) is combined with lipids, its surfactant-like property imparts to the combination significant pulmonary biophysical activity. Such a combination results in enhanced adsorption of the lipids with properties similar to that of natural pulmonary surfactant material. SAP(Val) and/or SAP(Phe) in combination with lipids is highly useful for replacing or supplementing natural pulmonary surfactant material for reducing or maintaining normal surface tension in the lungs, especially in the lungs of patients suffering from hyaline membrane disease, HMD, or other syndromes associated with the lack or insufficient amounts of natural pulmonary surfactant material. A combination of SAP(Val) and/or SAP(Phe) and lipids may be administered as an aerosol spray or in aqueous normal saline with or without calcium chloride for treating or preventing HMD and other surfactant deficiency states. Also disclosed are methods of isolating the SAP(Val) from animal tissue and methods for making SAP(Val) and SAP(Phe) by recombinant DNA techniques and direct peptide synthesis; genomic clones of SAP(Val) and SAP(Phe); expression systems and products for SAP(Val) DNA; and polyclonal and monoclonal antibodies to SAP(Val) and SAP(Phe).

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