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IC:C12P19/34 AND EN_ALLTXT:(coronavirus OR coronaviruses OR coronaviridae OR coronavirinae OR orthocoronavirus OR orthocoronaviruses OR orthocoronaviridae OR orthocoronavirinae OR betacoronavirus OR betacoronaviruses OR betacoronaviridae OR betacoronavirinae OR sarbecovirus OR sarbecoviruses OR sarbecoviridae OR sarbecovirinae OR "severe acute respiratory syndrome" OR sars OR "2019 ncov" OR covid)

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1 / 54
1.20080044814Oligonucleotides, reagents and amplification methods for detecting severe acute respiratory syndrome coronavirus
US - 21.02.2008
国际分类 C12Q 1/70
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
Q包含酶、核酸或微生物的测定或检验方法;其所用的组合物或试纸;这种组合物的制备方法;在微生物学方法或酶学方法中的条件反应控制
1包含酶、核酸或微生物的测定或检验方法;其组合物;这种组合物的制备方法
70包括病毒或噬菌体
 申请号 10552327 申请人 Genome Institute of Singapore 发明人 Ren Ee Chee

This invention provides oligonucleotides, reagents and amplification methods for detecting the severe acute respiratory syndrome coronavirus (SARS CoV). This invention also provides related compositions, kits, systems, and computers.

2.20050142536Method and kit for the detection of a novel coronoavirus associated with the severe acute respiratory syndrome (SARS)
US - 30.06.2005
国际分类 C12Q 1/68
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
Q包含酶、核酸或微生物的测定或检验方法;其所用的组合物或试纸;这种组合物的制备方法;在微生物学方法或酶学方法中的条件反应控制
1包含酶、核酸或微生物的测定或检验方法;其组合物;这种组合物的制备方法
68包括核酸
 申请号 10837026 申请人 QIAGEN Diagnostics GmbH 发明人 Laue Thomas

The instant invention relates to a quantitative real time RT-PCR method for detecting Severe Acute Respiratory Syndrome-associated virus (SARS-associated virus) and to oligonucleotides and kits for detecting SARS-associated virus.

3.WO/2005/042767COMPOSITIONS AND METHODS FOR DETECTING SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS
WO - 12.05.2005
国际分类 C12P 19/34
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
P发酵或使用酶的方法合成目标化合物或组合物或从外消旋混合物中分离旋光异构体
19含有糖残基的化合物的制备
26含氮碳水化合物的制备
28N-glycosides
30核苷酸
34多核苷酸,如核酸、寡核糖核苷酸
 申请号 PCT/US2004/036689 申请人 DIAGNOSTIC HYBRIDS, INC. 发明人 SCHOLL, David, R.
The invention provides compositions and methods for detecting the presence of SARS-coronavirus, for screening anti-SARS coronavirus agents and vaccines, and for reducing infection with plus-strand RNA viruses such as SARS-coronavirus.
4.20050037338Method and means for detection of severe acute respiratory syndrome
US - 17.02.2005
国际分类 C12P 19/34
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
P发酵或使用酶的方法合成目标化合物或组合物或从外消旋混合物中分离旋光异构体
19含有糖残基的化合物的制备
26含氮碳水化合物的制备
28N-glycosides
30核苷酸
34多核苷酸,如核酸、寡核糖核苷酸
 申请号 10640032 申请人 发明人 Tseng Kuo-Tang

A diagnostic means and method of detecting the presence or the absence of severe acute respiratory syndrome coronavirus antibody in a test sample. The means comprises a solid support, an unlabeled recombinant antigen peptide on a first area of the solid support, a labeled recombinant antigen peptide on a second area of the solid support and an internal control antibody peptide on a third area of the solid phase. The first area is located between the second and the third area.

5.20060263847Compositions and methods for treatment of severe acute respiratory syndrome (SARS)
US - 23.11.2006
国际分类 A61K 39/215
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
39含有抗原或抗体的医药配制品
12病毒性抗原
215冠状病毒科,例如禽传染性支气管炎病毒
 申请号 10557479 申请人 Wyeth 发明人 Siber George R.

Compositions and methods for treating Severe Acute Respiratory Syndrome (SARS) are disclosed herein. Inhibitors of SARS-associated inflammatory cytokines are provided herein for use in treating SARS, including SARS-associated coronavirus (SARS-CoV) infection. Inhibitors of TNF are disclosed herein, as is the use of said inhibitors for treating SARS, including SARS-CoV. Methods of identifying and screening for said inhibitors are also provided.

6.20070099178Method for detecting SARS coronavirus
US - 03.05.2007
国际分类 C12Q 1/68
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
Q包含酶、核酸或微生物的测定或检验方法;其所用的组合物或试纸;这种组合物的制备方法;在微生物学方法或酶学方法中的条件反应控制
1包含酶、核酸或微生物的测定或检验方法;其组合物;这种组合物的制备方法
68包括核酸
 申请号 10561947 申请人 Eiken Kagaku Kabushiki Kaisha 发明人 Minekawa Harumi

This invention provides: a method for detecting SARS pathogenic viruses with high sensitivity and rapidity for diagnosing severe acute respiratory syndrome (SARS); an oligonucleotide primer that can specifically hybridize with any nucleotide sequence constructed based on the nucleotide sequence of RNA polymerase of the SARS coronavirus; a method for nucleic acid amplification using such primer; a method for diagnosing infection with the SARS coronavirus via detection of nucleic acid amplification; and a kit for diagnosing SARS.

7.20220401550Nucleic acid vaccine against the SARS-CoV-2 coronavirus
US - 22.12.2022
国际分类 A61K 39/215
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
39含有抗原或抗体的医药配制品
12病毒性抗原
215冠状病毒科,例如禽传染性支气管炎病毒
 申请号 17819187 申请人 INSTITUT PASTEUR 发明人 Etienne Simon-Loriere

The invention relates to an immunogenic or vaccine composition against the 2019 novel coronavirus (SARS-CoV-2), comprising a nucleic acid construct encoding a SARS-CoV-2 coronavirus Spike (S) protein antigen or a fragment thereof comprising the receptor-binding domain, wherein the nucleic acid construct sequence is codon-optimized for expression in human.

8.20090226885Nucleic acid sequences that can be used as primers and probes in the amplification and detection of SARS coronavirus
US - 10.09.2009
国际分类 C07H 21/04
C化学;冶金
07有机化学
H糖类;及其衍生物;核苷;核苷酸;核酸
21含有两个或多个单核苷酸单元的化合物,具有以核苷基的糖化物基团连接的单独的磷酸酯基或多磷酸酯基,例如核酸
04有脱氧核糖基作为糖化物基团的
 申请号 10559949 申请人 Biomerieux, B.V. 发明人 Sillekens Peter T. G.

The present invention is related to nucleic acid sequences that can be used in the field of virus diagnostics, more specifically the diagnosis of infections with a novel human coronavirus causing Severe Acute Respiratory Syndrome (SARS). With the present invention nucleotide sequences are provided that can be used as primers and probes in the amplification and detection of SARS nucleic acid. The oligonucleotide sequences provided with the present invention are located in the replicase gene, the nucleocapsid gene and the 3′ end non-coding region of the SARS Coronavirus genome. It has been found that, by using the sequences of the present invention in methods for the amplification and detection of nucleic acid a sensitive and specific detection of SARS Coronavirus can be obtained. The oligonucleotide sequences according to the present invention are especially useful in methods for the amplification of nucleic acid.

9.20040229211Sensitive diagnostic testing methodology using multiplex real time PCR with one dye (MOD) and its use as in severe acute respiratory syndrome (SARS)
US - 18.11.2004
国际分类 C12P 19/34
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
P发酵或使用酶的方法合成目标化合物或组合物或从外消旋混合物中分离旋光异构体
19含有糖残基的化合物的制备
26含氮碳水化合物的制备
28N-glycosides
30核苷酸
34多核苷酸,如核酸、寡核糖核苷酸
 申请号 10455043 申请人 发明人 Yeung Wah Hin Alex

This invention provides a new and more sensitive methodology for multiplex real time PCR testing of any genetic materials. The method is best illustrated here with the detection and diagnosis of Severe Acute Respiratory Syndrome (SARS) but can be applicable to any other usage where more sensitivity is required. It can be combined with the usual multiplex real time PCR test for further confirmation and multiple parameter assessment of SARS or other diseases. A kit form is provided for the detection of SARS by this methodology, but equally applicable to other diseases or testing conditions.

10.WO/2021/183899METHODS AND KITS FOR THE DETECTION OF SARS-COV-2
WO - 16.09.2021
国际分类 C12P 19/34
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
P发酵或使用酶的方法合成目标化合物或组合物或从外消旋混合物中分离旋光异构体
19含有糖残基的化合物的制备
26含氮碳水化合物的制备
28N-glycosides
30核苷酸
34多核苷酸,如核酸、寡核糖核苷酸
 申请号 PCT/US2021/022128 申请人 THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE 发明人 ENGELTHALER, David
Methods, kits, and oligonucleotides used in the detection of coronavirus, for example, SARS-CoV-2, CoV-HKU1, CoV-OC43, CoV-229E, and CoV-NL63, are disclosed. A method of detecting coronavirus may include contacting a sample with at least one primer pair and probe targeting SARS-CoV-2 and at least one of: a primer pair and probe targeting CoV-HKU1, a primer pair and probe targeting CoV-OC43, a primer pair and probe targeting CoV-229E, a primer pair and probe targeting CoV-NL63, subjecting the mixture to conditions that allow nucleic acid amplification, and detecting the presence or absence of coronavirus, including SARS-CoV-2, CoV-HKU1, CoV-OC43, CoV-229E, and/or CoV-NL63, by analyzing the nucleic acid amplification products.
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