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IC:C12P AND EN_ALLTXT:(coronavirus OR coronaviruses OR coronaviridae OR coronavirinae OR orthocoronavirus OR orthocoronaviruses OR orthocoronaviridae OR orthocoronavirinae OR betacoronavirus OR betacoronaviruses OR betacoronaviridae OR betacoronavirinae OR sarbecovirus OR sarbecoviruses OR sarbecoviridae OR sarbecovirinae OR "severe acute respiratory syndrome" OR sars OR "2019 ncov" OR covid)

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1 / 237
1.WO/2021/207962ANTIBODIES TO SARS-CORONAVIRUS (COVID-19) S1 SPIKE PROTEIN
WO - 21.10.2021
国际分类 C07K 16/10
C化学;冶金
07有机化学
K肽
16免疫球蛋白,例如,单克隆或多克隆抗体
08抗来自病毒的物质
10来自RNA病毒
 申请号 PCT/CN2020/084857 申请人 ACTIVE MOTIF SHANGHAI LIMITED 发明人 LU, Yanan
Provided are recombinant monoclonal antibodies that bind to the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2 or COVID-19) spike protein and using methods thereof. The antibodies can inhibit or neutralize SARS-CoV-2 activity, thus can be used for treating or preventing or diagnosing COVID-19 infection in humans.
2.20060240551Neutralizing monoclonal antibodies against severe acute respiratory syndrome-associated coronavirus
US - 26.10.2006
国际分类 C12P 21/08
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
P发酵或使用酶的方法合成目标化合物或组合物或从外消旋混合物中分离旋光异构体
21肽或蛋白质的制备
08单克隆抗体
 申请号 11351108 申请人 New York Blood Center, Inc. 发明人 Jiang Shibo

The present invention provides an isolated antibody capable of binding to the receptor-binding domain of the spike protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) so as to competitively inhibit the binding of the SARS-CoV to host cells. These mAbs or substances can be used: 1) as passive-immunizing agents for prevention of SARS-CoV infection; 2) as biological reagents for diagnosis of SARS-CoV infection; 3) as immunotherapeutics for early treatment of SARS-CoV infection; and 4) as probes for studying the immunogenicity, antigenicity, structure, and function of the SARS-CoV S protein.

3.20080044814Oligonucleotides, reagents and amplification methods for detecting severe acute respiratory syndrome coronavirus
US - 21.02.2008
国际分类 C12Q 1/70
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
Q包含酶、核酸或微生物的测定或检验方法;其所用的组合物或试纸;这种组合物的制备方法;在微生物学方法或酶学方法中的条件反应控制
1包含酶、核酸或微生物的测定或检验方法;其组合物;这种组合物的制备方法
70包括病毒或噬菌体
 申请号 10552327 申请人 Genome Institute of Singapore 发明人 Ren Ee Chee

This invention provides oligonucleotides, reagents and amplification methods for detecting the severe acute respiratory syndrome coronavirus (SARS CoV). This invention also provides related compositions, kits, systems, and computers.

4.20050142536Method and kit for the detection of a novel coronoavirus associated with the severe acute respiratory syndrome (SARS)
US - 30.06.2005
国际分类 C12Q 1/68
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
Q包含酶、核酸或微生物的测定或检验方法;其所用的组合物或试纸;这种组合物的制备方法;在微生物学方法或酶学方法中的条件反应控制
1包含酶、核酸或微生物的测定或检验方法;其组合物;这种组合物的制备方法
68包括核酸
 申请号 10837026 申请人 QIAGEN Diagnostics GmbH 发明人 Laue Thomas

The instant invention relates to a quantitative real time RT-PCR method for detecting Severe Acute Respiratory Syndrome-associated virus (SARS-associated virus) and to oligonucleotides and kits for detecting SARS-associated virus.

5.WO/2005/042767COMPOSITIONS AND METHODS FOR DETECTING SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS
WO - 12.05.2005
国际分类 C12P 19/34
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
P发酵或使用酶的方法合成目标化合物或组合物或从外消旋混合物中分离旋光异构体
19含有糖残基的化合物的制备
26含氮碳水化合物的制备
28N-glycosides
30核苷酸
34多核苷酸,如核酸、寡核糖核苷酸
 申请号 PCT/US2004/036689 申请人 DIAGNOSTIC HYBRIDS, INC. 发明人 SCHOLL, David, R.
The invention provides compositions and methods for detecting the presence of SARS-coronavirus, for screening anti-SARS coronavirus agents and vaccines, and for reducing infection with plus-strand RNA viruses such as SARS-coronavirus.
6.WO/2021/202952COMPOSITIONS INCORPORATING SULFATED POLYSACCHARIDES FOR INHIBITING SARS-COV-2
WO - 07.10.2021
国际分类 A61K 31/727
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
31含有机有效成分的医药配制品
70碳水化合物;糖;其衍生物
715多糖类,即含有5个以上彼此通过配糖键相连的糖基的;其衍生物,例如醚、酯
726糖胺聚糖,即粘多糖
727肝素;类肝素
 申请号 PCT/US2021/025500 申请人 LINHARDT, Robert, John 发明人 LINHARDT, Robert, John
The composition inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via competitive binding to SARS-CoV-2 spike protein. The composition includes a plurality of sulfated glycosaminoglycans which bind to SARS-CoV-2 spike protein, preventing binding to and uptake by host cells. The sulfated glycosaminoglycans, including N-, 2-O, 3-O, or 6-O sulfate groups, or combinations thereof, include heparins and fucoidans, such as those isolated from brown seaweed. The compositions show antiviral activity, with EC50 as low as 0.08 μΜ, and low cytotoxicity, making it promising for clinical use. While established SARS-CoV-2 treatments such as remdesivir need to be administered intravenously, the compositions discussed herein are advantageously capable to being delivered as a nasal spray, metered dose inhaler, oral delivery, etc.
7.WO/2022/060900SHARK-DERIVED BINDING MOLECULES FOR SARS-COV-2 CORONAVIRUS AND USES THEREOF
WO - 24.03.2022
国际分类 A61K 39/395
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
39含有抗原或抗体的医药配制品
395抗体;免疫球蛋白;免疫血清,例如抗淋巴细胞血清
 申请号 PCT/US2021/050545 申请人 THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. 发明人 JOYCE, Michael Gordon
Disclosed herein are shark-derived antibodies and binding molecules with high binding affinity for SARS-CoV-2 coronavirus and the use thereof. Some of the shark-derived antibodies and binding molecules also demonstrate cross-reactivity with and neutralization of other related sarbecoviruses. The complementarity determining region (CDR) sequences and binding characteristics for these antibodies and binding molecules are provided. Also disclosed are the use of these antibodies and binding molecules to detect SARS-CoV-2 coronavirus or other related sarbecoviruses or to prevent or treat SARS-CoV-2 coronavirus or other related sarbecovirus infections.
8.20070092936Severe acute respiratory syndrome
US - 26.04.2007
国际分类 C12Q 1/68
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
Q包含酶、核酸或微生物的测定或检验方法;其所用的组合物或试纸;这种组合物的制备方法;在微生物学方法或酶学方法中的条件反应控制
1包含酶、核酸或微生物的测定或检验方法;其组合物;这种组合物的制备方法
68包括核酸
 申请号 10553844 申请人 HAYNES BARTON F 发明人 Haynes Barton F.

The present invention relates, in general, to severe acute respiratory syndrome and, in particular, to a method of generating neutralizing antibodies to the virus. The invention further relates to methods of detecting the presence of the virus and to methods of treating infected individuals.

9.20110097730Recombinant SARS-CoV nsp12 and the use of thereof and the method for producing it
US - 28.04.2011
国际分类 C12N 15/50
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
N微生物或酶;其组合物;繁殖、保藏或维持微生物;变异或遗传工程;培养基。
15突变或遗传工程;遗传工程涉及的DNA或RNA,载体(如质粒)或其分离、制备或纯化;所使用的宿主
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31编码微生物蛋白质,如内毒素的基因
33编码病毒蛋白质的基因
40来自RNA病毒,如黄色病毒的蛋白质
50冠状病毒科,如传染性支气管炎病毒、可传播性胃肠炎病毒
 申请号 12997816 申请人 Oh Jong Won 发明人 Oh Jong Won

The present invention relates to a recombinant severe acute respiratory syndrome coronavirus (SARS-CoV) non-structural protein (nsp) 12 with an RNA polymerase activity, its expression vector, its preparation method, and its use. According to the present invention, a soluble recombinant SARS-CoV nsp12 with an RdRp activity of initiating SARS-CoV genome synthesis can be over-expressed in the transformed host cells, and conveniently purified with high purity. An in vitro replication system important for studying SARS-CoV replication can be established with the purified recombinant SARS-CoV nsp12. SARS-CoV nsp12 produced by the present invention can also be used as a target for the development of anti-viral agents against SARS-CoV. In addition, materials inhibiting RNA-dependent RNA polymerase (RdRp) activity of nsp12 can be screened efficiently according to the present invention as the optimal conditions for the RdRp assay with SARS-CoV nsp12 were found.

10.20050037338Method and means for detection of severe acute respiratory syndrome
US - 17.02.2005
国际分类 C12P 19/34
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
P发酵或使用酶的方法合成目标化合物或组合物或从外消旋混合物中分离旋光异构体
19含有糖残基的化合物的制备
26含氮碳水化合物的制备
28N-glycosides
30核苷酸
34多核苷酸,如核酸、寡核糖核苷酸
 申请号 10640032 申请人 发明人 Tseng Kuo-Tang

A diagnostic means and method of detecting the presence or the absence of severe acute respiratory syndrome coronavirus antibody in a test sample. The means comprises a solid support, an unlabeled recombinant antigen peptide on a first area of the solid support, a labeled recombinant antigen peptide on a second area of the solid support and an internal control antibody peptide on a third area of the solid phase. The first area is located between the second and the third area.

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