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IC:C12N7/00 AND EN_ALLTXT:(coronavirus OR coronaviruses OR coronaviridae OR coronavirinae OR orthocoronavirus OR orthocoronaviruses OR orthocoronaviridae OR orthocoronavirinae OR betacoronavirus OR betacoronaviruses OR betacoronaviridae OR betacoronavirinae OR sarbecovirus OR sarbecoviruses OR sarbecoviridae OR sarbecovirinae OR "severe acute respiratory syndrome" OR sars OR "2019 ncov" OR covid)

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1 / 256
1.WO/2014/045254HUMAN BETACORONAVIRUS LINEAGE C AND IDENTIFICATION OF N-TERMINAL DIPEPTIDYL PEPTIDASE AS ITS VIRUS RECEPTOR
WO - 27.03.2014
国际分类 C12N 7/00
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
N微生物或酶;其组合物;繁殖、保藏或维持微生物;变异或遗传工程;培养基。
7病毒,如噬菌体;其组合物;其制备或纯化
 申请号 PCT/IB2013/058772 申请人 ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM 发明人 HAAGMANS, Bartholomeus, Leonardus
The invention provides an isolated essentially mammalian positive-sense single stranded RNA virus classifiable as belonging to the Order: Nidovirales; Family: Coronaviridae; Subfamily: Coronavirinae; Genus: Betacoronavirus; and non-Lineage A, non-Lineage B or non-Lineage D, human betacoronavirus. The invention also provides a human virus having a receptor binding domain (RBD) capable of binding to a dipeptidyl peptidase 4. The invention also provides diagnostic means and methods, prophylactic means and methods and therapeutic means and methods to be employed in the diagnosis, prevention and/or treatment of disease, in particular of respiratory disease, in particular of mammals, more in particular in humans.
2.WO/2022/175436INFLUENZA VIRUS DEFECTIVE INTERFERING PARTICLES FOR USE IN THE PROPHYLACTIC OR THERAPEUTIC TREATMENT OF CORONAVIRIDAE INFECTION
WO - 25.08.2022
国际分类 A61P 31/14
A人类生活必需
61医学或兽医学;卫生学
P化合物的治疗活性
31抗感染药,即抗生素、抗菌剂、化疗剂
12抗病毒剂
14用于RNA病毒的
 申请号 PCT/EP2022/054047 申请人 MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. 发明人 KUPKE, Sascha
The present invention relates in a first aspect to the use of influenza virus defective interfering particles in the prophylactic or therapeutic treatment of coronaviridae infection. In particular, it has been recognized that defective interfering particles of influenza A have beneficial effects in the treatment of SARS coronavirus infection, in particular, SARS-CoV-2 infection. Further, the present invention relates to a pharmaceutical composition for use in treating coronaviridae infection, in particular SARS-CoV-2. In a further aspect, methods for the prophylactic or therapeutic treatments of coronaviridae based on the administration of DIFs are disclosed.
3.20210246170Compositions and methods for preventing and treating coronavirus infection—SARS-CoV-2 vaccines
US - 12.08.2021
国际分类 C07K 14/005
C化学;冶金
07有机化学
K肽
14具有多于20个氨基酸的肽;促胃液素;生长激素释放抑制因子;促黑激素;其衍生物
005来自病毒
 申请号 17163357 申请人 Janssen Pharmaceuticals, Inc. 发明人 Johannes Petrus Maria Langedijk

The invention relates to immunogenic compositions and vaccines containing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; also referred to as SARS-CoV-2)) protein or a polynucleotide encoding a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) protein and uses thereof. The invention also provides methods of treating and/or preventing a coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) infection by administering an immunogenic composition or vaccine to a subject (e.g., a human). The invention also provides methods of detecting and/or monitoring a protective anti-coronavirus (e.g., Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) antibody response (e.g., anti-coronavirus antibody response, e.g., anti-2019-nCoV antibody response, e.g., anti-Spike antibody response, e.g., anti-Spike neutralizing antibody response). The present invention relates to isolated nucleic and/or recombinant nucleic acid encoding a coronavirus S protein, in particular a SARS-CoV-2 S protein, and to the coronavirus S proteins, as well as to the use of the nucleic acids and/or proteins thereof in vaccines.

4.WO/2021/206783VACCINATION AGAINST CORONAVIRUS WITH POLIOMYELITIS VACCINE
WO - 14.10.2021
国际分类 A61K 39/13
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
39含有抗原或抗体的医药配制品
12病毒性抗原
125小RNA病毒科,例如嵌环状病毒属
13脊髓灰质炎病毒
 申请号 PCT/US2021/014253 申请人 XIE, Qiyi 发明人 XIE, Qiyi
Provided herein is a poliomyelitis vaccine for use in preventing a person from an infection by a Coronaviridae virus. Also provided herein is a poliomyelitis vaccine for use in inducing a protective immune response in a person against a Coronaviridae virus.
5.WO/2018/160977CORONAVIRUSES, VACCINES COMPRISING THE SAME, AND METHODS FOR PREVENTING DISEASE
WO - 07.09.2018
国际分类 C12N 7/00
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
N微生物或酶;其组合物;繁殖、保藏或维持微生物;变异或遗传工程;培养基。
7病毒,如噬菌体;其组合物;其制备或纯化
 申请号 PCT/US2018/020678 申请人 LOYOLA UNIVERSITY CHICAGO 发明人 BAKER, Susan
Coronaviruses, vaccines comprising the same, and methods for preventing disease. One embodiment of such includes a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a non-structural protein (nsp)-15, the replicase gene encoding the nsp15 and causes any change, including mutations and/or deletions, that affects the stability or activity of the nsp15.
6.WO/2022/023734CORONAVIRAL PACKAGING SIGNALS
WO - 03.02.2022
国际分类 A61K 39/12
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
39含有抗原或抗体的医药配制品
12病毒性抗原
 申请号 PCT/GB2021/051934 申请人 UNIVERSITY OF LEEDS 发明人 CLARK, Sam
The present invention relates to virus like particles, vaccines and delivery vectors utilising coronavirus packaging signals, and therapeutic agents targeting such packaging signals.
7.WO/2023/010176VACCINE CONSTRUCT AND USES THEREOF
WO - 09.02.2023
国际分类 C07K 14/005
C化学;冶金
07有机化学
K肽
14具有多于20个氨基酸的肽;促胃液素;生长激素释放抑制因子;促黑激素;其衍生物
005来自病毒
 申请号 PCT/AU2022/050843 申请人 THE UNIVERSITY OF MELBOURNE 发明人 TORESSI, Joseph
Disclosed herein are nucleic acid constructs for producing a virus-like particle (VLP) capable of raising an immune response against severe acute respiratory syndrome coronavirus (SARS-CoV), and uses thereof, wherein the constructs comprise nucleic acid sequences encoding an immunogen and a polyprotein, wherein the polyprotein comprises two or more viral structural proteins, wherein at least two of the two or more viral structural proteins are separated by a signal peptidase sequence such that, when the polyprotein is expressed in a host cell, the signal peptidase sequence undergoes host cell peptidase-dependent cleavage to liberate the two or more viral structural proteins, thereby allowing the liberated structural proteins to self-assemble into a VLP carrying the immunogen.
8.20230190915T CELL EPITOPES AND RELATED COMPOSITIONS USEFUL IN THE PREVENTION, DIAGNOSIS, AND TREATMENT OF COVID-19
US - 22.06.2023
国际分类 A61K 39/215
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
39含有抗原或抗体的医药配制品
12病毒性抗原
215冠状病毒科,例如禽传染性支气管炎病毒
 申请号 17795181 申请人 EPIVAX, INC. 发明人 Anne De Groot

The present disclosure generally relates to novel epitope-based compositions, including vaccines, against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and diseases caused by SARS-CoV-2, including the highly contagious coronavirus disease 2019 (which has been termed and may be referred to herein as “COVID-19”, “2019-nCoV”, or the “2019 novel coronavirus”. The disclosure relates to immunogenic polypeptides and the uses thereof, particularly in vaccine compositions. The disclosure also relates to nucleic acids, vectors, and cells which express the polypeptides and the uses thereof. The polypeptides more specifically comprise an agretope predicted to be a ligand of HLA class I and/or HLA class II MHC molecules, as well as an epitope that is predicted to be recognized by T-cells in the context of MHC class I and/or class II molecules. The compositions are particularly suited to produce vaccines, particularly for vaccinating against SARS-CoV-2 infection and related diseases caused by SARS-CoV-2, including COVID-19.

9.10948490Severe acute respiratory syndrome (SARS)—associated coronavirus diagnostics
US - 16.03.2021
国际分类 G01N 33/569
G物理
01用于测量的传感器,如敏感元件
N借助于测定材料的化学或物理性质来测试或分析材料
33利用不包括在G01N1/00至G01N31/00组中的特殊方法来研究或分析材料
48生物物质,例如血、尿;血球计数器
50生物物质(例如血、尿)的化学分析;包括了生物特有的配体结合方法的测试;免疫学试验
53免疫测定法;生物特异性结合测定;相应的生物物质
569用于微生物,例如原生动物、细菌、病毒
 申请号 16944649 申请人 INSTITUT PASTEUR 发明人 Sylvie Van Der Werf

The invention relates to the diagnosis of a SARS-associated coronavirus, such as a SARS CoV-2 infection and SARS-CoV infection, using the SARS-CoV and SARS-CoV-2 nucleocapsid proteins and antibodies binding to these proteins. The invention encompasses reagents, methods and kits for the detection of a SARS-associated coronavirus.

10.WO/2023/100159MULTICISTRON EXPRESSION VECTOR FOR COVID-19 VACCINE
WO - 08.06.2023
国际分类 A61K 39/215
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
39含有抗原或抗体的医药配制品
12病毒性抗原
215冠状病毒科,例如禽传染性支气管炎病毒
 申请号 PCT/IB2022/061742 申请人 KASHIV BIOSCIENCES, LLC 发明人 GUPTA, Sudharti
The present invention provides an expression vector comprises gene of interest encode more than one structural protein to enhance immune responses against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its variants. Further, the present invention the expression vector comprises spike protein of SARS-CoV-2 and one or more structural protein selected from membrane protein, envelope protein and nucleocapsid protein of SARS-CoV-2. The expression vector expressed mRNA capable to encode more than one structural protein to provide immune response against SARS-CoV-2 virus.
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