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1 / 3,253
1.WO/2024/106532CARBON-DIOXIDE-REDUCING INTERIOR ACCESSORY
WO - 23.05.2024
国际分类 C12M 3/00
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
M酶学或微生物学装置
3组织、人类、动物或植物细胞或病毒培养装置
 申请号 PCT/JP2023/041421 申请人 SHELTER JAPAN CO., LTD. 发明人 YANO Akihiko
Provided is a carbon-dioxide-reducing interior accessory that is easy to maintain and manage and has a high degree of design freedom. A culture vessel 10 in which an algal culture broth L1 is stored has an inner wall provided in a ring shape and an outer wall provided in a ring shape in a region outside the inner wall, an opening also being formed in the culture vessel. The culture vessel 10 also comprises a light source device 20 that irradiates the inner wall with light, the light emitted from the light source device 20 being visible through the inner wall, the algal culture broth L1, and the outer wall. External air EA that is blown into the algal culture broth L1 from an external air introduction nozzle 41, in the process of rising through the algal culture broth L1, reduces carbon dioxide and generates oxygen, which is discharged from the opening, through the effect of photosynthesis by algae present in the algal culture broth L1.
2.WO/2024/105481用于生物医学研究的金属制器官芯片
WO - 23.05.2024
国际分类 C12M 3/06
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
M酶学或微生物学装置
3组织、人类、动物或植物细胞或病毒培养装置
06用过滤、超滤、反向渗透或透析方法
 申请号 PCT/IB2023/060890 申请人 KOLN HONG KONG LIMITED 发明人 YAU, Wing Fung Edmond
用于生物医学研究的金属制器官芯片，至少包括一器官芯片单元；所述单元由至少一组用于生物质或培养基在其内流动的微流体通道；以及沿所述通道设置的观察窗口组成；所述单元采用生物兼容性金属制造。用于模仿肌肉骨胳系统的医学植入物的器官芯片，该装置结合了微流体装置中培养的活细胞，模拟组织-植入物反应及活体器官的器官水平功能，器官芯片允许细胞在与活体内相似的药理学条件下在体外培养，用于研究包括细胞-细胞相互作用反应。通过在器官芯片内覆盖生物或治疗涂层，或浸没在生物缓冲下，或含药物释放微结构下，模拟了在金属与细胞的自然状态，为筛选、毒理实验和功效测量提供预测价值。
3.WO/2024/107345SYSTEMS AND METHODS OF DIFFERENTIATING STEM CELLS WITHIN BIOREACTOR
WO - 23.05.2024
国际分类 C12N 5/00
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
N微生物或酶;其组合物;繁殖、保藏或维持微生物;变异或遗传工程;培养基。
5未分化的人类、动物或植物细胞,如细胞系;组织;它们的培养或维持;其培养基
 申请号 PCT/US2023/036732 申请人 CORNING INCORPORATED 发明人 BAILEY, Himabindu Nandivada
A method of using a cell culture bioreactor for differentiating stem cells in situ in the bioreactor is provided. The method includes providing a bioreactor vessel that has a cell culture chamber with an inlet for flowing fluid into the cell culture chamber and an outlet for flowing fluid out of the cell culture chamber. The bioreactor vessel also includes a cell substrate disposed in the cell culture chamber for culturing cells thereon. The method includes seeding undifferentiated stem cells onto the cell substrate in the cell culture chamber and perfusing the cell culture chamber with a differentiation media to promote differentiation of the undifferentiated stem cells into a specified cell lineage, whereby the undifferentiated stem cells become differentiated cells.
4.WO/2024/104434用于生产目标物质的系统和方法
WO - 23.05.2024
国际分类 C12M 3/00
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
M酶学或微生物学装置
3组织、人类、动物或植物细胞或病毒培养装置
 申请号 PCT/CN2023/132083 申请人 OXFORD UNIVERSITY (SUZHOU) SCIENCE & TECHNOLOGY CO., LTD. 发明人 LEI, Rui
本申请涉及一种用于生产目标物质的系统和方法。所述系统包括培养装置、第一培养溶液供给装置、第二培养溶液供给装置、和培养物供给单元。培养装置布置为经由滤膜将培养装置分隔为生长区和培养液循环区，第一培养溶液供给装置布置为经由所述第一入口和所述第一出口与所述生长区流体连通，第二培养溶液供给装置布置为经由所述第二入口和所述第二出口与所述培养液循环区流体连通，培养物供给单元布置为经由所述第一入口与所述生长区流体连通。所述系统能够以工艺简单且高效的方式获得更高产率的目标物质。
5.WO/2024/105224MICROPHYSIOLOGICAL SYSTEM
WO - 23.05.2024
国际分类 C12M 1/32
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
M酶学或微生物学装置
1酶学或微生物学装置
26接种器或采样器
32多层型或连续型
 申请号 PCT/EP2023/082179 申请人 UNIVERSITE DU LUXEMBOURG 发明人 WILMES, Paul
The disclosure relates to a microphysiological system comprising a frame with a base (7) exhibiting a surface (9) for receiving a cell culture support, a lid for closing the microphysiological system, and locking means fastening the frame and the lid when said microphysiological system is closed, the microphysiological system is remarkable in that the base (7) is disposed within the frame on a support plate (17) displaceable between a high position when the microphysiological system is open and a low position when the microphysiological system is closed and in that the support plate (17) is movable vertically between its high position and low position with elastic means (19) configured to bring the support plate (17) back to the high position.
6.WO/2024/106334DEVICE, OBSERVATION METHOD, RECOVERY METHOD, CULTURE METHOD, AND DEVICE MANUFACTURING METHOD
WO - 23.05.2024
国际分类 C12M 1/34
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
M酶学或微生物学装置
1酶学或微生物学装置
34用条件测量或信号传感方法测量或检验,如菌落计数器
 申请号 PCT/JP2023/040557 申请人 TOKYO OHKA KOGYO CO., LTD. 发明人 OHSAKA Takashi
A device (1) provided with a plurality of units (3) having sample chambers (2) capable of individually accommodating cells or particles, wherein each unit (3) comprises a storage layer (5) having an accommodation part (4) corresponding to a sample chamber (2), and a structure (6) for circulating a liquid to the accommodation part (4), and the plurality of units (3) are independent of each other, with no circulation of the liquid therebetween.
7.WO/2024/107798MODULAR ADJUSTABLE BIOREACTOR FOR DECELLULARIZATION AND CELL SEEDING
WO - 23.05.2024
国际分类 A61F 2/04
A人类生活必需
61医学或兽医学;卫生学
F可植入血管内的滤器;假体;为人体管状结构提供开口、或防止其塌陷的装置,例如支架;整形外科、护理或避孕装置;热敷;眼或耳的治疗或保护;绷带、敷料或吸收垫;急救箱
2可植入血管中的滤器;假体,即用于人体各部分的人造代用品或取代物;用于假体与人体相连的器械;对人体管状结构提供开口或防止塌陷的装置,例如支架(stents)
02能移植到体内的假体
04空心的或管状的器官,例如膀胱、气管、支气管或胆管
 申请号 PCT/US2023/079747 申请人 RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL 发明人 CHIANG, Tendy
An adjustable, modular bioreactor has been developed for both partial or full decellularization of organs or tissues and recellularization of the decellularized organs or tissues. The allows for the use of different end pieces to secure different diameters of the tissue to be treated, and is adjustable in length, for example, using a slidable chamber housing, which can be shortened or lengthened merely by sliding of an endpiece, where the chamber remains sealed through the use of an O-ring or other seal and the endpiece is secured in position with a clamp.
8.WO/2024/100279MICROFLUIDIC DEVICE FOR CELL COMPRESSION
WO - 16.05.2024
国际分类 B01L 3/00
B作业;运输
01大类中的化学工艺及装置;
L化学或物理实验设备
3实验室用的容器或器皿,如实验室玻璃仪器;点滴器
 申请号 PCT/EP2023/081505 申请人 THE UNIVERSITY OF YORK 发明人 REZK, Rasha Saber Mohamed Mahmoud
The disclosure concerns a microfluidic device suitable for mechanically compressing cells without the necessity of adhering cells onto a substrate, methods for mechanically compressing cells and mechanically compressed cells obtained by the method are also disclosed.
9.WO/2024/099598A MODULAR INCUBATOR SYSTEM
WO - 16.05.2024
国际分类 C12M 3/00
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
M酶学或微生物学装置
3组织、人类、动物或植物细胞或病毒培养装置
 申请号 PCT/EP2023/066987 申请人 ESCO MEDICAL TECHNOLOGIES, UAB 发明人 NIELSEN, Ricky Lindgaard
A modular incubator system (500) for incubating a viable biological material M is disclosed. The modular incubator system comprises one or more modular incubator chambers (300) in combination with a docking station (400). In respect of one or more of said one or more modular incubator chambers (300), said modular incubator chamber (300) comprises a housing (302) wherein said housing (302) of said modular incubator chamber (300) comprises a transparent window (316) for enabling capturing of images of a biological material M being accommodated in the interior thereof, through said transparent window. The docking station (400) comprises one or more docking ports (402) for receiving a housing (302) of one or more of said incubator chambers (300) and in respect of one or more docking ports (402) of said docking station (400), said docking port comprises an image capturing device (408) for capturing an image of the interior (306) of a modular incubator chamber (300), once being docked in said docking port (402). The housing (302) of the modular incubator chamber (300) comprises a shutter mechanism (344), wherein said shutter mechanism is configured to be able to shift between an open configuration and a closed configuration and vice versa. Hereby excessive exposure to light of the viable biological material can be avoided, and thereby more optimum incubation conditions for the viable biological material is provided.
10.20240160183CONTEXT-AWARE AUGMENTATION OF DIGITAL THREE-DIMENSIONAL MODEL
US - 16.05.2024
国际分类 G05B 19/4099
G物理
05大类的关于设备控制的小类可能包括的由模拟装置产生的控制功能;
B一般的控制或调节系统;这种系统的功能单元;用于这种系统或单元的监视或测试装置
19程序控制系统
02电的
18数字控制(NC),即在特殊机床中的自动操作机器,例如在1个制造设施中通过以数字形式的程序数据来执行定位、移动或协调操作
4097以使用设计数据来控制NC机为特征的,例如CAD/CAM
4099表面或曲线机械加工,制成3D物品,例如写字桌顶部的制造
 申请号 18054987 申请人 INTERNATIONAL BUSINESS MACHINES CORPORATION 发明人 Saraswathi Sailaja Perumalla

A computer-implemented method for augmentation and printing of a three-dimensional (3D) object is provided. The computer-implemented method includes analyzing a model of the 3D object, information of sensors for deployment on the 3D object and environmental parameters of a location where the 3D object is deployable and determining, from results of the analyzing, a surface contour of the 3D object, power requirements of the sensors and power levels that can be generated at the location by algae-based power generation. The computer-implemented method further includes augmenting the model with microfluidic circuitry models for supporting the algae-based power generation on the surface contour to meet the power requirements to an extent possible given the power levels, printing the 3D object and microfluidic circuitry according to the model and the microfluidic circuitry models and supplying the microfluidic circuitry with algae for the algae-based power generation.

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