WIPO – 检索国际和国家专利汇编

1.WO/2024/103297样品提取卡盒和样品提取方法及核酸检测设备

WO - 23.05.2024

国际分类 C12N 5/0784 申请号 PCT/CN2022/132302 申请人 GUANGZHOU NATIONAL LABORATORY 发明人 JIANG, Taijiao

一种样品提取卡盒和样品提取方法及核酸检测设备，可广泛应用于生物医药仪器技术领域。样品提取卡盒包括卡盒基座（1000）和多个腔室组合，腔室组合包括第一腔室（2101）、第二腔室（2102）、第一混合腔室（2201）、第二混合腔室（2202）、第三腔室（2103）和第四腔室（2104），第一腔室（2101）用于存放保存液，第二腔室（2102）用于存放洗涤液，第二混合腔室（2202）用于存放裂解液，第三腔室（2103）用于连通气源，第四腔室（2104）用于存放洗脱液；卡盒基座（1000）设置多个液路组合。腔室组合的各腔室与液路组合的各液路对应通断，实现样液的混合、洗涤、清理残液、洗脱及出液，提高提取、检测效率，且废液存放在第一腔室（2101），提高结构利用率。设计样品扩增卡盒具有多个腔室组合和多个液路组合，获得多通道并联的卡盒结构，能够同步处理样液。

2.WO/2024/103373保持真空恒定的系统、方法以及基因测序仪

WO - 23.05.2024

国际分类 C12M 1/00 申请号 PCT/CN2022/132784 申请人 MGI TECH CO., LTD. 发明人 LU, Hao

保持真空恒定的系统，包括负压吸附对象、吸附支撑件、流体动力装置（4）和流体控制阀（3），所述吸附支撑件用于支撑所述负压吸附对象，所述流体动力装置（4）通过管路与所述吸附支撑件连通，用于对所述吸附支撑件抽真空以吸附所述负压吸附对象，所述流体控制阀（3）设置在所述流体动力装置（4）与所述吸附支撑件连通的管路上，用于切换或增加抽真空的所述流体动力装置；所述流体控制阀（3）至少设置一个，所述流体动力装置（4）至少设置两个。所述的保持真空恒定的系统，降低了流体动力装置的失效导致的检测任务出错的概率。还提供了一种保持真空恒定的方法和一种基因测序仪。

3.WO/2024/107798MODULAR ADJUSTABLE BIOREACTOR FOR DECELLULARIZATION AND CELL SEEDING

WO - 23.05.2024

国际分类 A61F 2/04 申请号 PCT/US2023/079747 申请人 RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL 发明人 CHIANG, Tendy

An adjustable, modular bioreactor has been developed for both partial or full decellularization of organs or tissues and recellularization of the decellularized organs or tissues. The allows for the use of different end pieces to secure different diameters of the tissue to be treated, and is adjustable in length, for example, using a slidable chamber housing, which can be shortened or lengthened merely by sliding of an endpiece, where the chamber remains sealed through the use of an O-ring or other seal and the endpiece is secured in position with a clamp.

4.WO/2024/107348SYSTEMS AND METHODS FOR COATING A BIOREACTOR SUBSTRATE

WO - 23.05.2024

国际分类 C12M 1/00 申请号 PCT/US2023/036770 申请人 CORNING INCORPORATED 发明人 BAILEY, Himabindu Nandivada

A method of coating a cell culture substrate in situ in a bioreactor is provided that includes providing a bioreactor vessel having a cell culture chamber with an inlet for flowing fluid into the cell culture chamber and an outlet for flowing fluid out of the cell culture chamber, and a cell substrate disposed in the cell culture chamber for culturing cells. The method includes providing a coating solution for coating the cell substrate; inputting the coating solution into the cell culture chamber such that the coating solution contacts the cell substrate; and removing an excess of the coating solution from the cell culture chamber. After removing the coating solution, a coated cell substrate remains in the cell culture chamber.

5.20240166980PHOTOBIOREACTOR FABRICATION SYSTEM

US - 23.05.2024

国际分类 C12M 1/00 申请号 18516092 申请人 Korea University Research and Business Foundation 发明人 Sang Jun SIM

A photobioreactor fabrication system is disclosed. According to a first embodiment, the photobioreactor fabrication system includes a first unwinder 10 continuously unwinding a first transparent film 1, a second unwinder 20 arranged parallel to the first unwinder 10 and continuously unwinding a second transparent film 2 such that the second film 2 faces the first film 1, a heat sealer 30 pressurizing and heat sealing the first 1 and second films 2 to a baffle 3 arranged between the first 1 and second films 2 facing each other, and a rewinder 40 simultaneously and continuously winding the first 1 and second films 2 having passed through the heat sealer 30.

6.WO/2024/106532CARBON-DIOXIDE-REDUCING INTERIOR ACCESSORY

WO - 23.05.2024

国际分类 C12M 3/00 申请号 PCT/JP2023/041421 申请人 SHELTER JAPAN CO., LTD. 发明人 YANO Akihiko

Provided is a carbon-dioxide-reducing interior accessory that is easy to maintain and manage and has a high degree of design freedom. A culture vessel 10 in which an algal culture broth L1 is stored has an inner wall provided in a ring shape and an outer wall provided in a ring shape in a region outside the inner wall, an opening also being formed in the culture vessel. The culture vessel 10 also comprises a light source device 20 that irradiates the inner wall with light, the light emitted from the light source device 20 being visible through the inner wall, the algal culture broth L1, and the outer wall. External air EA that is blown into the algal culture broth L1 from an external air introduction nozzle 41, in the process of rising through the algal culture broth L1, reduces carbon dioxide and generates oxygen, which is discharged from the opening, through the effect of photosynthesis by algae present in the algal culture broth L1.

7.WO/2024/106442EVALUATION METHOD OF FILTRATION CONDITION AND PRODUCTION METHOD OF CELL PRODUCT

WO - 23.05.2024

国际分类 C12P 21/08 申请号 PCT/JP2023/040996 申请人 ASAHI KASEI MEDICAL CO., LTD. 发明人 MATSUDA, Shun

A method for evaluating filtration condition(s), the method including: under conditions where cell growth is suppressed, feeding a culture fluid containing cells from a culture tank 11 containing the culture fluid to a porous membrane 12, returning the culture fluid, which has passed through the porous membrane 12 without being filtered, back to the culture tank 11 so as to circulate the culture fluid between the culture tank 11 and the porous membrane 12; and evaluating one or more filtration conditions in the porous membrane 12.

8.20240167923Bioengineered and standardized Human Tissue Reference Controls for Validation of IHC, FISH or CISH Cancer Test Results

US - 23.05.2024

国际分类 G01N 1/36 申请号 18219342 申请人 SLMP, LLC 发明人 Syed Ashraf IMAM

A method of making a tissue reference control block is disclosed wherein cancer cells are selected with a known positivity or negativity for a specific marker and cancer cells are grown to a certain phase. The cancer cells are screened for an expression of the specific marker and the screened cancer cells are mixed with stromal cells and co-cultured in a bio-reactor bag. A spheroid grown from the co-cultured mixture of cells is harvested, fixed, and embedded in a core of a paraffin block.

9.20240166981MICROBIOLOGICAL TESTING DEVICE, MICROBIOLOGICAL TESTING ASSEMBLY AND CAP FOR A MICROBIOLOGICAL TESTING DEVICE

US - 23.05.2024

国际分类 C12M 1/12 申请号 18057257 申请人 Tintometer GmbH 发明人 James P. GOODMAN

A microbiological testing device (10), comprises a growth medium support plate (12) and a cap (14) attached to the growth medium support plate (12), the growth medium support plate (12) comprising a microbiological testing area (60), wherein the microbiological testing area (60) comprises at least one recess (66) for receiving a microbiological growth medium (62), wherein the least one recess (66) comprises a bottom surface (68) and at least one anchoring element (74) protruding from the bottom surface (68), and wherein the at least one anchoring element (74) comprises an undercut (76) for engaging with the microbiological growth medium (62). Further, a microbiological testing assembly and a cap for the microbiological testing device are described.

10.WO/2024/104434用于生产目标物质的系统和方法

WO - 23.05.2024

国际分类 C12M 3/00 申请号 PCT/CN2023/132083 申请人 OXFORD UNIVERSITY (SUZHOU) SCIENCE & TECHNOLOGY CO., LTD. 发明人 LEI, Rui

本申请涉及一种用于生产目标物质的系统和方法。所述系统包括培养装置、第一培养溶液供给装置、第二培养溶液供给装置、和培养物供给单元。培养装置布置为经由滤膜将培养装置分隔为生长区和培养液循环区，第一培养溶液供给装置布置为经由所述第一入口和所述第一出口与所述生长区流体连通，第二培养溶液供给装置布置为经由所述第二入口和所述第二出口与所述培养液循环区流体连通，培养物供给单元布置为经由所述第一入口与所述生长区流体连通。所述系统能够以工艺简单且高效的方式获得更高产率的目标物质。

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