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1.20210304408Assessment of abnormality regions associated with a disease from chest CT images

US - 30.09.2021

国际分类 G06T 7/00 申请号 16837979 申请人 Siemens Healthcare GmbH 发明人 Shikha Chaganti

Systems and methods for assessing a disease are provided. Medical imaging data of lungs of a patient is received. The lungs are segmented from the medical imaging data and abnormality regions associated with a disease are segmented from the medical imaging data. An assessment of the disease is determined based on the segmented lungs and the segmented abnormality regions. The disease may be COVID-19 (coronavirus disease 2019) or diseases, such as, e.g., SARS (severe acute respiratory syndrome), MERS (Middle East respiratory syndrome), or other types of viral and non-viral pneumonia.

2.WO/2021/247682METHODS FOR MITIGATING OR DIMINISHING SPREAD OF PATHOGENIC INFECTIONS

WO - 09.12.2021

国际分类 G16H 50/80 申请号 PCT/US2021/035421 申请人 ROSS, Peter M. 发明人 ROSS, Peter M.

The present methods comprise initial administration of a first rapid test, such as rapid antigen test, that has a low likelihood of false positive results and a known likelihood of false negative results, alone or in conjunction with other rapid tests, to identify a first subpopulation of positives, to which an infection mitigation protocol (such as quarantine or the administration of a therapeutic treatment) is administered. Negatives are recorded and provisionally released from further study. A diagnostic test is then administered to this subpopulation, to identify the portion of this first subpopulation that were false positives in the first test. Ideally, a positive result for the diagnostic test is pathognomonic for the infection. Any infection mitigation protocol (such as quarantine) may then be discontinued for those testing negative in the first population and intensified for those testing positive, such as with contact tracing or other protocols, to identify all true positives and those they may have infected within the population.

3.WO/2022/015912METHODS AND DEVICES FOR THE RAPID DETECTION OF SARS-COV-2/COVID-19 DISEASE

WO - 20.01.2022

国际分类 A61B 5/157 申请号 PCT/US2021/041723 申请人 THE UNIVERSITY OF MASSACHUSETTS 发明人 CAMCI-UNAL, Gulden

Multilayer diagnostic microfluidic devices for the capture of a present or past SARS-CoV-2 infection and/or COVID-19 disease from a fluid sample using a multiplexed ELISA-based assay and their methods of use are described herein. The devices comprise a sample application layer comprising a sample application zone: a conjugation layer comprising a conjugation reagent in a conjugation zone, wherein the conjugation reagent comprises a detectable marker; a capture layer comprising a capture reagent in a capture zone; and an absorbent layer. The layers above tire capture layer are removable to expose a detectable signal in the capture zone. Detectable analytes include a SARS-CoV-2 protein or an antigenic fragment thereof, an IgM, IgG, or IgA antibody associated with a SARS-CoV-2 infection and or COVID-19 disease, or an inflammatory biomarker associated with a SARS-CoV-2 infection and/or COVID-19 disease.

4.WO/2022/177466THE USE OF THE AGENT FOR INDUCING IMMUNITY TO SARS-COV-2

WO - 25.08.2022

国际分类 G01N 33/53 申请号 PCT/RU2022/000046 申请人 FEDERAL STATE BUDGETARY INSTITUTION "NATIONAL RESEARCH CENTER FOR EPIDEMIOLOGY AND MICROBIOLOGY NAMED AFTER THE HONORARY ACADEMICIAN N.F. GAMALEYA" OF THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION 发明人 ZUBKOVA, Olga Vadimovna

Group of invention relates to biotechnology, immunology and virology. Described is the use of an agent containing expression vector based on strain human adenovirus serotype 26 or human adenovirus serotype 5, in which E1 and E3 regions are deleted, with integrated expression cassette selected from SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, or simian adenovirus serotype 25, in which E1 and E3 regions are deleted with integrated expression cassette selected from SEQ ID NO:4, SEQ ID NO:2, SEQ ID NO:3 or contains only component 2 for providing prolongation of post-vaccination immunity against SARS-CoV-2. Also an agent can containing any two of said components. The group of inventions allows producing safe and effective agents providing prolongation of post-vaccination immunity against SARS-CoV-2 and is aimed at population revaccination against severe acute respiratory syndrome SARS-CoV-2.

5.20210315461Methods of diagnosing and treating viral infections

US - 14.10.2021

国际分类 A61B 5/01 申请号 17229185 申请人 Ibrahim Saud Almishari 发明人 Ibrahim Saud Almishari

Diagnosing and treating viral infections. One example is a method of diagnosing absence of severe acute respiratory syndrome 2 (SARS-CoV-2), the method including: isolating a human in a covid-free environment for an isolation period; performing measurements of a core temperature during the isolation period; and if each of the measurements of the core temperature indicate a lack of fever, declaring the human free of SARS-CoV-2. Another example is a method including treating coronavirus in a human by: receiving a core temperature measurement; receiving a test result regarding the SARS-CoV-2 virus; responsive to the human having both fever and the presence of the SARS-CoV-2 virus, submerging the trunk and the legs of the human in water with a surfactant, and the human at least partially submerged for a treatment period of at least three hours; and controlling a temperature of the water during the treatment period.

6.WO/2024/036192COMPOSITIONS AND METHODS FOR ASSESSING THE SEVERITY OF AND TREATING COVID-19

WO - 15.02.2024

国际分类 C12Q 1/6827 申请号 PCT/US2023/071902 申请人 THE JOHNS HOPKINS UNIVERSITY 发明人 JOHNS, Roger

The present invention relates to the field of virology. More specifically, the present invention provides compositions and methods for assessing the severity of and treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19. In particular embodiments, a method for treating COVID-19 in a patient comprises the step of administering to the patient an isolated, recombinant antibody or antigen-binding fragment thereof that binds human Resistin.

7.WO/2022/159886BIOLOGICS DETECTION DEVICE

WO - 28.07.2022

国际分类 G06T 7/00 申请号 PCT/US2022/013690 申请人 ADVANCED MEDICAL SOLUTIONS INTERNATIONAL, LLC 发明人 SAID, Nassar, O.

Methods and apparatus for non-invasively and accurately detecting a chemically- stable molecular structure. The methods and apparatus can be used to detect molecules associated with disease and disorders, and objects or subjects associated with such disease and disorders, such as contaminated with the molecules or pathogens, or having disease or disorder associated with the molecules or pathogens.

8.WO/2022/133258REAL-TIME PREDICTION OF ADVERSE OUTCOMES USING MACHINE LEARNING

WO - 23.06.2022

国际分类 A61B 5/02 申请号 PCT/US2021/064106 申请人 THE JOHNS HOPKINS UNIVERSITY 发明人 SHADE, Julie, K.

Provided herein are methods of generating models for prognosing cardiovascular outcomes for monitored subjects infected with an etiologic agent (e.g., severe acute respiratory syndrome coronavirus-2 or another etiologic agent). Related methods, systems, and computer program products are also provided.

9.WO/2022/256741SENSOR FOR DETECTING BIOMARKERS IN A FLUID SAMPLE AND METHODS OF USE

WO - 08.12.2022

国际分类 C12Q 1/68 申请号 PCT/US2022/032379 申请人 ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 发明人 MUTHUSWAMY, Jitendran

The invention relates to a diagnostic platform for detection of biomarkers associated with a particular condition, disease, or disorder and methods of making and using the same. In various embodiments, the diagnostic platform includes a sensing device and an electronic reading platform. Aspects of the invention are directed to a diagnostic platform for detection of at least one biomarker in a fluid sample. In embodiments, the diagnostic platform comprises a sensing device configured to receive the fluid sample. The platform can further comprise an electronic reading platform and a computing device. The electronic reading platform can be configured to activate the sensor.

10.WO/2022/013877METHOD AND SYSTEM FOR PREPARING A SAMPLE FOR DETECTION OF PROTEINS

WO - 20.01.2022

国际分类 A61B 5/08 申请号 PCT/IL2021/050869 申请人 BREATH OF HEALTH LTD. 发明人 LAOR, Marsel Arie

The present invention provides a system including a pump configured to pump an air sample, from a container to a cooling chamber, at a capacity of at least 0.5 liter/sec, the cooling chamber is configured to cool the exhaled air sample to a sub-zero temperature, and is in fluid connection to a spectrometer test chamber; an inert gas source, configured to supply an inert gas to the test chamber at a pressure higher than the atmospheric pressure; and a heating unit for heating said air sample. Further provided is a method for preparing an air sample for detection of a mixture of proteins.

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