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IC:C07K14/165 AND EN_ALLTXT:(coronavirus OR coronaviruses OR coronaviridae OR coronavirinae OR orthocoronavirus OR orthocoronaviruses OR orthocoronaviridae OR orthocoronavirinae OR betacoronavirus OR betacoronaviruses OR betacoronaviridae OR betacoronavirinae OR sarbecovirus OR sarbecoviruses OR sarbecoviridae OR sarbecovirinae OR "severe acute respiratory syndrome" OR sars OR "2019 ncov" OR covid)

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1 / 135
1.WO/2021/211792TREATMENT OF CORONAVIRUS INFECTIONS WITH AURANOFIN
WO - 21.10.2021
国际分类 A61K 31/7135
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
31含有机有效成分的医药配制品
70碳水化合物;糖;其衍生物
7135含有重金属的化合物
 申请号 PCT/US2021/027404 申请人 GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 发明人 KUMAR, Mukesh
The present disclosure provides methods for treating viral infections, in particular treating coronavirus infections in a subject with auranofin.
2.WO/2021/163456T CELL EPITOPES AND RELATED COMPOSITIONS USEFUL IN THE PREVENTION, DIAGNOSIS, AND TREATMENT OF COVID-19
WO - 19.08.2021
国际分类 A61K 39/215
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
39含有抗原或抗体的医药配制品
12病毒性抗原
215冠状病毒科,例如禽传染性支气管炎病毒
 申请号 PCT/US2021/017825 申请人 EPIVAX, INC. 发明人 DE GROOT, Anne
The present disclosure generally relates to novel epitope-based compositions, including vaccines, against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and diseases caused by SARS-CoV-2, including the highly contagious coronavirus disease 2019 (which has been termed and may be referred to herein as "COVID-19", "2019-nCoV", or the "2019 novel coronavirus". The disclosure relates to immunogenic polypeptides and the uses thereof, particularly in vaccine compositions. The disclosure also relates to nucleic acids, vectors, and cells which express the polypeptides and the uses thereof. The polypeptides more specifically comprise an agretope predicted to be a ligand of HLA class I and/or HLA class II MHC molecules, as well as an epitope that is predicted to be recognized by T-cells in the context of MHC class I and/or class II molecules. The compositions are particularly suited to produce vaccines, particularly for vaccinating against SARS-CoV-2 infection and related diseases caused by SARS-CoV-2, including COVID-19.
3.WO/2021/229591NOVEL USE OF NON-IONIC SURFACTANT FOR THE TREATMENT OF COVID–19
WO - 18.11.2021
国际分类 A61K 9/00
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
9以特殊物理形状为特征的医药配制品
 申请号 PCT/IN2020/050643 申请人 KRISHNAMACHARI, Ramu 发明人 RITHVIK, K
The present invention relates to a novel use of non-ionic surfactants for the treatment of diseases caused by viruses. The present invention particularly relates to the use of non-ionic surfactants for the treatment of a disease known as COVID 19 caused by coronavirus SARS-CoV-2. The present invention further teaches the use of taste masking agents/excipients. The present invention is further believed to be related to cleansing the coronaviruses from buccal cavities, throat or within the body of a subject by not allowing the said virus to attach to any cells of mucosal layers or epithelial cells thus allowing them to pass out of the body or getting digested inside the body. For this reason the molecules or the composition used herein of the present invention is termed by the applicant as "INTERNAL SOAP".
4.WO/2021/163398T CELL EPITOPE CLUSTERS AND RELATED COMPOSITIONS USEFUL IN THE PREVENTION, DIAGNOSIS, AND TREATMENT OF COVID-19
WO - 19.08.2021
国际分类 A61K 39/215
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
39含有抗原或抗体的医药配制品
12病毒性抗原
215冠状病毒科,例如禽传染性支气管炎病毒
 申请号 PCT/US2021/017748 申请人 EPIVAX, INC. 发明人 DE GROOT, Anne
The present disclosure relates to novel epitope-based compositions, including vaccines, against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and diseases caused by SARS-CoV-2, including the highly contagious coronavirus disease 2019. The disclosure relates to immunogenic polypeptides (including concatemeric polypeptides, hybrid Ii-key constructs, and chimeric or fusion polypeptides as disclosed herein) and the uses thereof, particularly in vaccine compositions. The disclosure also relates to nucleic acids, vectors, and cells which express the polypeptides and the uses thereof. The polypeptides of the invention more specifically comprise an agretope predicted to be a ligand of HLA class I and/or HLA class II MHC molecules, as well as an epitope that is predicted to be recognized by T-cells in the context of MHC class I and/or class II molecules. The compositions are particularly suited to produce vaccines, particularly for vaccinating against SARS-CoV-2 infection and related diseases caused by SARS-CoV-2, including COVID-19.
5.WO/2021/198999EPITOPE-BASED VACCINES FOR TREATMENT OF CORONAVIRUS ASSOCIATED DISEASES
WO - 07.10.2021
国际分类 C07K 11/00
C化学;冶金
07有机化学
K肽
11在完全确定的序列中最多含有20个氨基酸的缩肽,其衍生物
 申请号 PCT/IB2021/052781 申请人 AXON NEUROSCIENCE SE 发明人 ZILKA, Norbert
The disclosures described herein relate to polypeptides, antibodies, and compositions for use in the treatment and diagnosis of severe acute respiratory syndrome (SARS) coronavirus-associated diseases or disorders. Provided are new immunogenic compositions related to SARS CoV2 S protein and method of preventing and/or treating severe acute respiratory syndrome and other SARS-CoV-related disease, including COVID-19. Also provided are diagnostic reagents for the detection of SARS virus, SARS Cov2 S protein, a complex of SARS Cov2 S protein and ACE2, and/or severe acute respiratory syndrome or other SARS-CoV-related disease.
6.WO/2023/030476IMMUNOGENIC COMPOSITIONS AND METHODS FOR IMMUNIZATION AGAINST VARIANTS OF SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2)
WO - 09.03.2023
国际分类 C07K 14/165
C化学;冶金
07有机化学
K肽
14具有多于20个氨基酸的肽;促胃液素;生长激素释放抑制因子;促黑激素;其衍生物
005来自病毒
08RNA viruses
165冠状病毒科,例如鸟的传染性支气管炎病毒
 申请号 PCT/CN2022/116668 申请人 MEDIGEN VACCINE BIOLOGICS CORPORATION 发明人 CHEN, Charles
Provided are immunogenic compositions and methods for immunization against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially an immunogenic composition having a recombinant SARS-CoV-2 S protein derived from Beta (B. 1.351) variant and methods using an immunogenic composition derived from SARS-CoV-2 Beta (B. 1.351) variant.
7.WO/2023/079472MULTICISTRON EXPRESSION VECTOR FOR COVID-19 VACCINE
WO - 11.05.2023
国际分类 C12N 15/85
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
N微生物或酶;其组合物;繁殖、保藏或维持微生物;变异或遗传工程;培养基。
15突变或遗传工程;遗传工程涉及的DNA或RNA,载体(如质粒)或其分离、制备或纯化;所使用的宿主
09Recombinant DNA-technology
63使用载体引入外来遗传物质;载体;其宿主的使用;表达的调节
79专门适用于真核细胞宿主的载体或表达系统
85用于动物细胞
 申请号 PCT/IB2022/060586 申请人 KASHIV BIOSCIENCES, LLC 发明人 GUPTA, Sudharti
The present invention provides an expression vector comprises gene of interest encode more than one structural protein to enhance immune responses against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its variants. Furthermore, the expression vector to produce mRNA expresses more than one structural protein to generate immune response against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its variants.
8.3173187METHODS FOR TREATMENT OF CORONAVIRUS INFECTIONS
CA - 14.10.2021
国际分类 A61K 31/195
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
31含有机有效成分的医药配制品
185酸;酐、卤化物或其盐类,例如硫酸类、亚氨酸、腙酸或羟肟酸
19羧酸;例如丙戊酸
195含氨基的
 申请号 3173187 申请人 UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. 发明人 TRIPP, RALPH A.
Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or analog thereof, or a pharmaceutically acceptable salt thereof. The methods can be therapeutic and/or prophylactic. The amount of probenecid, metabolite or analog thereof, or pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a Severe acute respiratory syndrome-related coronavirus such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-related coronavirus such as MERS-CoV, or a coronavirus that causes the common cold.
9.WO/2021/254473IMMUNOGENIC COMPOSITION AGAINST SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2)
WO - 23.12.2021
国际分类 C12N 15/50
C化学;冶金
12生物化学;啤酒;烈性酒;果汁酒;醋;微生物学;酶学;突变或遗传工程
N微生物或酶;其组合物;繁殖、保藏或维持微生物;变异或遗传工程;培养基。
15突变或遗传工程;遗传工程涉及的DNA或RNA,载体(如质粒)或其分离、制备或纯化;所使用的宿主
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31编码微生物蛋白质,如内毒素的基因
33编码病毒蛋白质的基因
40来自RNA病毒,如黄色病毒的蛋白质
50冠状病毒科,如传染性支气管炎病毒、可传播性胃肠炎病毒
 申请号 PCT/CN2021/100826 申请人 MEDIGEN VACCINE BIOLOGICS CORPORATION 发明人 KUO, Tsun-Yung
Provided an immunogenic composition against severe acute respiratory syndrome coronavirus (SARS-CoV-2), especially to an immunogenic composition having a recombinant SARS-CoV-2 S protein and adjuvant.
10.20210275665Immunogenic and vaccine compositions against SARS-CoV-2
US - 09.09.2021
国际分类 A61K 39/215
A人类生活必需
61医学或兽医学;卫生学
K医用、牙科用或梳妆用的制剂
39含有抗原或抗体的医药配制品
12病毒性抗原
215冠状病毒科,例如禽传染性支气管炎病毒
 申请号 17249546 申请人 Iowa State University Research Foundation, Inc. 发明人 Michael Wan Cho

Disclosed herein are immunogenic and/or vaccine compositions and methods for treating or preventing Severe acute respiratory syndrome (SARS). The compositions and methods include an immunogenic portion of the receptor-binding domain (RBD) of the SARS-CoV-2-2 (COVID-19) spike protein. In at least particular cases, a mutated version of a portion of the RBD is utilized, such as a deglycosylated, or amino acid substituted mutant of the spike protein.

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