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1. (WO2019067441) BIOPSY SITE MARKER WITH MICROSPHERE COATING
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We Claim:

1. A marker delivery device comprising:

a delivery catheter adapted to be inserted into a biopsy site, the delivery catheter having a discharge opening;

a marker having a coating layer disposed on the surface of a core, the coating layer containing an adhesive with a plurality of microbubbles configured to enhance visibility under ultrasound imaging, the marker being positioned inside the delivery catheter near the discharge opening; and

a push rod positioned within the delivery catheter and adapted to deploy the marker from the delivery catheter into the biopsy site.

2. The marker delivery device of claim 1, wherein the marker is enclosed in a bioabsorbable carrier.

3. The marker delivery device of claim 1, wherein the marker is enclosed in a bioabsorbable carrier whose volume is configured to expand upon contact with liquid inside the biopsy site.

4. The marker delivery device of claim 1, wherein the marker includes a metallic marker, ceramic marker, or plastic marker.

5. The marker delivery device of claim 1, further comprising a carrier, wherein the marker is wrapped around the carrier.

6. The marker delivery device of claim 1, wherein the plurality of microbubbles include gas-filled microparticles.

7. The marker delivery device of claim 1, wherein the plurality of microbubbles include gas-filled microparticles whose average size is less than 500 microns.

8. The marker delivery device of claim 1, wherein the plurality of microbubbles have an average size of less than 500 microns.

9. The marker delivery device of claim 1, wherein the plurality of microbubbles have an average size of between 1 and 250 microns.

10. The marker delivery device of claim 1, wherein the plurality of microbubbles have an average size of between 1 and 100 microns.

11. A method of manufacturing a marker delivery device comprising:

coating a biopsy site marker with microspheres;

drying the coated marker, the boating of the microspheres enhancing ultrasound visibility of the marker;

positioning the marker inside a delivery catheter near its discharge opening; and positioning a push rod within the delivery catheter, the push rod adapted to deploy the marker from the delivery catheter into the biopsy site.

12. The method of claim 11, further comprising the step of enclosing the marker within a bioabsorbable carrier.

13. The method of claim 11, further comprising the step of enclosing the marker within a bioabsorbable carrier whose volume is configured to expand upon contact with liquid inside the biopsy site.

14. The method of claim 11, wherein the marker includes a metallic marker, ceramic marker, or plastic marker.

15. The method of claim 11, further comprising the step of wrapping the marker around a bioabsorbable carrier.

16. The method of claim 11, wherein the plurality of microbubbles include gas-filled microparticles.

17. The method of claim 11, wherein the plurality of microbubbles include gas-filled microparticles whose average size is less than 500 microns.

18. The method of claim 11, wherein the plurality of microbubbles have an average size of less than 500 microns.

19. The method of claim 11, wherein the plurality of microbubbles have an average of between 1 and 250 microns.

20. A method of manufacturing a marker delivery device comprising:

selecting gas-filled microparticles whose average size is less than 500 microns;

mixing the selected microparticles with an adhesive to create a coating mixture;

applying the coating mixture to a marker element;

drying the marker element;

enclosing the dried marker element in a bioabsorbable carrier to form a biopsy site marker; and

positioning the biopsy site marker in a delivery catheter near a discharge opening for deployment into the biopsy site by a push rod positioned inside the delivery catheter.