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1. WO2018009603 - CHIMERIC WEST NILE/ZIKA VIRUSES AND METHODS OF USE


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2017/040818 4239-97038-02
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
06 July 2017 08 July 2016
Applicant
THE UNITED STATES OF AMERICA, AS REPRESENTED BY
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No.     1    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07K 14/005 (2006.01)i; C12N 7/00 (2006.01)i; A61K 39/12 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; C07K; C12N
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
Y
WO 2015196094 A1 (US HEALTH [US]) 23 December 2015 (2015-12-23)
1-44
the whole document
in particular page 18 line 24- page 19 line 30; page 22 line 7-page 30 line 30; examples 1 and 4; claims 1-47; Fig. 1B-1D
(2)
Y
SUZUKI R ET AL, "Construction and Characterization of a Single-Cycle Chimeric Flavivirus Vaccine Candidate That Protects Mice against Lethal Challenge with Dengue Virus Type 2", 01 February 2009 (2009-02-01), Vol. 83, No. 4, page 1870-1880,
XP002544715
[retrieved on  2008-12-10]
1-44
the whole document
in particular abstract; Fig. 1
(3)
Y
CHAO SHAN ET AL, "Zika Virus: Diagnosis, Therapeutics, and Vaccine", ACS INFECTIOUS DISEASES,Vol. 2, No. 3, 11 March 2016 (2016-03-11), page 170-172,
XP055276341
1-44
the whole document
in particular page 171 col. 2
(4)
Y
J. COHEN, "The race for a Zika vaccine is on", SCIENCE,Vol. 351, No. 6273, 05 February 2016 (2016-02-05), page 543-544,
XP055360676
1-44
the whole document
in particular page 543, col. 2 par. 1+col. 2 last par-col. 3 line 2
(5)
A
SHAN CHAO ET AL, "An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors", CELL HOST & MICROBE, ELSEVIER, NL,Vol. 19, No. 6, 16 May 2016 (2016-05-16), page 891-900,
XP029594479
1-44
the whole document
in particular page 894, col. 2, par. 2 and 3; page 898, Fig. 5
(6)
A,P
CHAO SHAN ET AL, "A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients", EBIOMEDICINE,Vol. 17, 01 March 2017 (2017-03-01), page 157-162,
XP055408946
28-44
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2015196094 A1
23 December 2015
AU 2015276929 A1
CN 106574271 A
EP 3158061 A1
US 2017114330 A1
WO 2015196094 A1
22 December 2016
19 April 2017
26 April 2017
27 April 2017
23 December 2015
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
25 September 2017
Date of mailing of the international search report:
04 October 2017
Authorized officer:
Dumont, Elisabeth
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