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1. MX2019003790 - ANALOGOS DE ISOXAZOL COMO AGONISTAS DE FXR Y METODOS DE USO DE LOS MISMOS.

Office Mexique
Numéro de la demande 2019003790
Date de la demande 02.04.2019
Numéro de publication 2019003790
Date de publication 26.09.2019
Type de publication A
CIB
C07D 413/14
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
DCOMPOSÉS HÉTÉROCYCLIQUES
413Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle
14contenant au moins trois hétérocycles
CPC
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
Déposants ENANTA PHARMACEUTICALS, INC.
Inventeurs Bin WANG
Yat Sun OR
Guoqiang WANG
Jun MA
Jing HE
Xuechao XING
Ruichao SHEN
Données relatives à la priorité 62/404,059 04.10.2016 US
Titre
(EN) ANALOGOS DE ISOXAZOL COMO AGONISTAS DE FXR Y METODOS DE USO DE LOS MISMOS.
(ES) ANALOGOS DE ISOXAZOL COMO AGONISTAS DE FXR Y METODOS DE USO DE LOS MISMOS.
Abrégé
(EN)
The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.

(ES)
La presente invención proporciona compuestos de Fórmula I, composiciones farmacéuticas que comprenden estos compuestos y métodos de uso de estos compuestos para prevenir o tratar enfermedades o afecciones mediadas por FXR o TGR5.