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1. KR1020150062204 - 난용성 약물이 봉입된 리포좀 나노입자를 포함하는 장기 안정성이 우수한 약학적 제제 및 이의 제조방법

Office République de Corée
Numéro de la demande 1020130146061
Date de la demande 28.11.2013
Numéro de publication 1020150062204
Date de publication 08.06.2015
Numéro de délivrance 1015616100000
Date de délivrance 22.10.2015
Type de publication B1
CIB
A61K 9/127
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
9Préparations médicinales caractérisées par un aspect particulier
10Dispersions; Emulsions
127Liposomes
A61K 47/30
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
47Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. les supports ou les additifs inertes; Agents de ciblage ou de modification chimiquement liés à l’ingrédient actif
30Composés macromoléculaires organiques ou inorganiques, p.ex. polyphosphates inorganiques
A61K 9/16
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
9Préparations médicinales caractérisées par un aspect particulier
14à l'état particulaire, p.ex. poudres
16Agglomérés; Granulés; Microbilles
CPC
A61K 9/1277
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1277Processes for preparing; Proliposomes
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 47/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
A61K 47/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 47/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
24containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 31/337
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
337having four-membered rings, e.g. taxol
Déposants 한국화학연구원
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventeurs CHO, SUN HANG
SHIN, BYUNG CHUL
SON, YEO WON
조선행
SUNG, HA SOO
신병철
CHOI, YOUN WOONG
손여원
YUK, SOON HONG
성하수
CHOA, SANG MIN
최연웅
육순홍
조상민
Mandataires 이원희
Titre
(KO) 난용성 약물이 봉입된 리포좀 나노입자를 포함하는 장기 안정성이 우수한 약학적 제제 및 이의 제조방법
Abrégé
(EN)
The present invention relates to a pharmaceutical medicine with excellent long-term stability comprising liposome nanoparticles-encapsulated poorly water soluble drugs and a manufacturing method thereof. According to the present invention, the size of liposome nanoparticles-encapsulated poorly water soluble drugs is from 30 to 900 nm, and a pharmaceutical medicine comprising the same improves solubility and bioavailability of the medicine with excellent long-term stability. In addition, the pharmaceutical medicine can be manufactured with an easy manufacturing method, thus can be applied for poorly water soluble drugs required for stability. COPYRIGHT KIPO 2015

(KO)
본 발명은 본 발명은 난용성 약물이 봉입된 리포좀 나노입자를 포함하는 장기 안정성이 우수한 약학적 제제 및 이의 제조방법에 관한 것으로써,본 발명에 따른 난용성 약물이 봉입된 리포좀 나노입자 크기는 30-900 nm로 이를 포함하는 약학적 제제의 용해도를 향상시키고, 장기 안정성이 우수하므로, 약물의 생체이용률을 향상시킬 수 있다. 또한, 상기 약학적 제제는 용이한 제조방법으로 제조할 수 있으므로 안정성이 필요한 난용성 약물에 유용하게 적용할 수 있다.