Traitement en cours

Veuillez attendre...

Paramétrages

Paramétrages

Aller à Demande

1. WO2020197493 - APPAREIL ET PROCÉDÉ DE MESURE NON INVASIVE DU DÉBIT SANGUIN DANS UN TISSU PROFOND

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

CLAIMS

1. An apparatus for non-invasively measuring blood flow in a deep tissue, comprising:

a multi-mode optical fiber having a sensing end and a distal end opposite to the sensing end, wherein the multi-mode optical fiber is configured to receive at the sensing end an optical signal emitted from the deep tissue and transmit the received optical signal towards the distal end;

an imaging device configured to capture an image of the transmitted optical signal at the distal end of the multi-mode optical fiber;

a filtering processor configured to remove a pre -determined background image from the captured image to generate a de -background image; and

a processor configured to determine a blood perfusion index from the generated de-background image, the blood perfusion index being indicative of an instantaneous blood flow measurement in the deep tissue.

2. The apparatus of claim 1, further comprising a light source configured to emit a beam of light transmissible to the deep tissue to be reflected or scattered as the optical signal emitted from the deep tissue.

3. The apparatus of claim 1, wherein the imaging device comprises a charge -coupled device (CCD) camera with a frame rate ranging between about 300 frames per second and 1000 frames per second.

4. The apparatus of claim 1, further comprising a calibration processor, wherein the imaging device is configured to capture a series of images of transmitted optical signals at the distal end, and wherein the calibration processor is configured to apply an averaging process to the series of images to generate the pre -determined background image.

5. The apparatus of claim 4, wherein the averaging process comprises a Gaussian process.

6. The apparatus of claim 4, wherein the calibration processor is at least part of the filtering processor or the processor.

7. The apparatus of claim 4, wherein the imaging device is configured to capture the series of about 6000 images of the transmitted optical signals at the distal end over a time period ranging between about 6 seconds and about 20 seconds.

8. The apparatus of claim 1, wherein the filtering processor is at least part of the processor.

9. The apparatus of claim 1, wherein the processor is further configured to determine a plurality of blood perfusion indexes from a plurality of de -background images obtained and processed from a plurality of images captured by the imaging device over a period of time, and display a cardiogram-like plot depicting a relationship between the plurality of blood perfusion indexes and time.

10. The apparatus of claim 1, wherein the apparatus is capable of measuring blood flow in the deep tissue at a rate of more than 300 Hz.

11. A method for non-invasively measuring blood flow in a deep tissue, the method comprising:

receiving an optical signal emitted from the deep tissue at a sensing end of a multi-mode optical fiber; wherein the received optical signal is transmitted to a distal end of the multi-mode optical fiber, the distal end being opposite to the sensing end;

capturing an image of the transmitted optical signal at the distal end of the multi -mode optical fiber;

removing a pre-determined background image from the captured image to generate a de -background image; and

determining a blood perfusion index from the generated de -background image, the blood perfusion index being indicative of an instantaneous blood flow measurement in the deep tissue.

12. The method of claim 11 , further comprising emitting a beam of light transmissible to the deep tissue that is reflected or scattered as the optical signal emitted from the deep tissue.

13. The method of claim 11, wherein the step of capturing the image comprises capturing the image using a charge-coupled device (CCD) camera with a frame rate ranging between about 300 frames per second and 1000 frames per second.

14. The method of claim 11, where the pre-determined background image is obtainable from capturing a series of images of transmitted optical signals at the distal end, and applying an averaging process to the series of images.

15. The method of claim 14, wherein the averaging process comprises a Gaussian process.

16. The method of claim 14, wherein capturing the series of images comprises capturing about 6000 images of the transmitted optical signals at the distal end over a time period ranging between about 6 seconds and about 20 seconds.

17. The method of claim 11, further comprising determining a plurality of blood perfusion indexes from a plurality of de -background images obtained and processed from a plurality of images of optical signals received by the multi -mode optical fiber captured over a period of time, and displaying a cardiogram-like plot depicting a relationship between the plurality of blood perfusion indexes and time.

18. The method of claim 17, wherein each of the plurality of de -background images is obtained from removing the pre-determined background image from each corresponding image of the plurality of images.

19. The method of claim 17, wherein the step of determining the plurality of blood perfusion indexes is performed in a manner to allow a measurement of blood flow in the deep tissue at a rate of more than 300 Hz.

20. The method of claim 11, wherein the step of determining the blood perfusion

( i

index comprises calculating the blood perfusion index with a formulae, - Y , where I

std J represents a mean intensity of pixels of the de -background image, and std represents a standard deviation of the pixels of the de -background image.