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1. WO2020072492 - DÉRIVÉS DE BENZAMIDE UTILISÉS EN TANT QU'AGONISTES DE LA VOIE CGAZ-STING

Numéro de publication WO/2020/072492
Date de publication 09.04.2020
N° de la demande internationale PCT/US2019/054065
Date du dépôt international 01.10.2019
CIB
C07D 471/04 2006.01
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
DCOMPOSÉS HÉTÉROCYCLIQUES
471Composés hétérocycliques contenant des atomes d'azote comme uniques hétéro-atomes du système condensé, au moins un cycle étant un cycle à six chaînons avec un atome d'azote, non prévus dans les groupes C07D451/-C07D463/254
02dans lesquels le système condensé contient deux hétérocycles
04Systèmes condensés en ortho
CPC
C07C 235/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
42having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
44with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
56having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C07D 231/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
54condensed with carbocyclic rings or ring-systems
56Benzopyrazoles; Hydrogenated benzopyrazoles
C07D 241/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02not condensed with other rings
10having three double bonds between ring members or between ring members and non-ring members
14with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 317/68
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
317Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08having the hetero atoms in positions 1 and 3
44ortho- or peri-condensed with carbocyclic rings or ring systems
46condensed with one six-membered ring
48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes unsubstituted on the hetero ring
62with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
68Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C07D 405/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Déposants
  • BARUCH S. BLUMBERG INSTITUTE [US]/[US]
Inventeurs
  • CHANG, Jinhong
  • DU, Yanming
  • GUO, Ju-tao
Mandataires
  • HEBLE, Nikhil, A.
Données relatives à la priorité
62/740,21002.10.2018US
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) BENZAMIDE DERIVATIVES AS CGAS-STING PATHWAY AGONISTS
(FR) DÉRIVÉS DE BENZAMIDE UTILISÉS EN TANT QU'AGONISTES DE LA VOIE CGAZ-STING
Abrégé
(EN)
Pharmaceutical compositions of the invention comprise functionalized benzamide derivatives useful as cyclic GMP-AMP synthase- Stimulator of interferon gene (cGAS-STING) pathway agonists, and useful for treating viral diseases and boost antitumor immunity.
(FR)
Les compositions pharmaceutiques de l'invention comprennent des dérivés de benzamide fonctionnalisés utiles en tant qu'agonistes de la voie GMA-AMP synthase-stimulateur de gènes d'interférons (cGAS-STING), et utiles pour le traitement de maladies virales et l'amplification de l'immunité antitumorale.
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