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1. WO2020022895 - SIGNATURES GÉNIQUES POUR PRÉDIRE LA MÉTASTASE D'UN MÉLANOME ET D'UN PRONOSTIC DE PATIENT


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/NL2019/050487
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
25 July 2019 25 July 2018
Applicant
SKYLINEDX B.V.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
This International Searching Authority found multiple inventions in this international application, as follows:
1. claims: 1-14, 19-24, 29-35(completely); 41-48(partially)
Method for classifying an individual afflicted with primary cutaneous melanoma, comprising determining in a sample from said individual a gene expression signature comprising three or more of genes ITGB3, PLAT, SPP1, GCF15, IL8. Methods for determining treatment or predicting prognosis based on said expression signature. Methods of treatment of an individual comprising determining said expression signature. Kits comprising primer pairs for amplifying said genes.
2. claims: 15-18, 25-28, 36-48(all partially)
Method for classifying an individual afflicted with primary cutaneous melanoma, comprising determining in a sample from said individual a gene expression signature comprising KRT14. Methods for determining treatment or predicting prognosis based on said expression signature. Methods of treatment of an individual comprising determining said expression signature. Kits comprising primer pairs for amplifying said genes.
3. claims: 15-18, 25-28, 36-48(all partially)
Method for classifying an individual afflicted with primary cutaneous melanoma, comprising determining in a sample from said individual a gene expression signature comprising SPP1. Methods for determining treatment or predicting prognosis based on said expression signature. Methods of treatment of an individual comprising determining said expression signature. Kits comprising primer pairs for amplifying said genes.
4. claims: 15-18, 25-28, 36-48(all partially)
Method for classifying an individual afflicted with primary cutaneous melanoma, comprising determining in a sample from said individual a gene expression signature comprising FN1. Methods for determining treatment or predicting prognosis based on said expression signature. Methods of treatment of an individual comprising determining said expression signature. Kits comprising primer pairs for amplifying said genes.
5. claims: 15-18, 25-28, 36-48(all partially)
Method for classifying an individual afflicted with primary cutaneous melanoma, comprising determining in a sample from said individual a gene expression signature comprising LOXL3. Methods for determining treatment or predicting prognosis based on said expression signature. Methods of treatment of an individual comprising determining said expression signature. Kits comprising primer pairs for amplifying said genes.
1.
As all required additional search fees were timely paid by the applicant, this international search report covers all searchable claims.
2.
As all searchable claims could be searched without effort justifying additional fees, this Authority did not invite payment of additional fees.
3.
As only some of the required additional search fees were timely paid by the applicant, this international search report covers only those claims for which fees were paid, specifically claims Nos.:
4.
No required additional search fees were timely paid by the applicant. Consequently, this international search report is restricted to the invention first mentioned in the claims; it is covered by claims Nos.: 1-14, 19-24, 29-35(completely); 41-48(partially)
Remark on Protest
The additional search fees were accompanied by the applicant’s protest and, where applicable, the payment of a protest fee.
The additional search fees were accompanied by the applicant’s protest but the applicable protest fee was not paid within the time limit specified in the invitation.
No protest accompanied the payment of additional search fees.
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No.     1    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C12Q 1/6886 (2018.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C12Q
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
US 2016222457 A1 (MEVES ALEXANDER [US] ET AL) 04 August 2016 (2016-08-04)
1-14,19-24,29-35,41-48
abstract; claim 7
paragraphs [0074] - [0080]
(2)
Y
WO 2016025717 A1 (MAYO FOUNDATION [US]) 18 February 2016 (2016-02-18)
1-14,19-24,29-35,41-48
page 2, line 24 - page 5, line 22; claims 1,8, 20
(3)
Y
US 2016115555 A1 (MA XIAO-JUN [US] ET AL) 28 April 2016 (2016-04-28)
1-14,19-24,29-35,41-48
paragraphs [0015] - [0033], [0153] - [0159]; claims 30,31
(4)
A
JÓZSEF TÍMÁR ET AL, "Gene signature of the metastatic potential of cutaneous melanoma: too much for too little?", CLINICAL & EXPERIMENTAL METASTASIS ; OFFICIAL JOURNAL OF THEMETASTASIS RESEARCH SOCIETY, KLUWER ACADEMIC PUBLISHERS, DO,Vol. 27, No. 6, 24 February 2010 (2010-02-24), page 371-387,
XP019815757
1-14,19-24,29-35,41-48
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
US 2016222457 A1
04 August 2016
US 2016222457 A1
US 2019338372 A1
WO 2014077915 A1
04 August 2016
07 November 2019
22 May 2014
WO 2016025717 A1
18 February 2016
US 2017275700 A1
WO 2016025717 A1
28 September 2017
18 February 2016
US 2016115555 A1
28 April 2016
AU 2011305696 A1
AU 2016210732 A1
EP 2619321 A2
US 2012071343 A1
US 2016115555 A1
WO 2012040168 A2
02 May 2013
25 August 2016
31 July 2013
22 March 2012
28 April 2016
29 March 2012
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
20 December 2019
Date of mailing of the international search report:
03 March 2020
Authorized officer:
Aguilera, Miguel
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