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1. (WO2017004231) ARTICLES ANTIMICROBIENS ET LEURS PROCÉDÉS D'UTILISATION
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

What is claimed is:

1. An article comprising:

an occlusive layer; and

a substrate having a nanostructured surface;

wherein the nanostructured surface is coated with a metal oxide layer;

wherein the metal oxide layer comprises a metal oxide.

2. The article of claim 1, wherein the metal oxide layer comprises less than 99 wt.% non-oxidized metal.

3. The article of claim 2, wherein the metal oxide layer comprises less than 95 wt.% non-oxidized metal.

4. The article of claim 3, wherein the nanostructured surface comprises an anisotropic nanostructure.

5. The article of claim 4, wherein the anisotropic nanostructure has an aspect ratio greater than 2: 1.

6. The article of any of claims 1 to 5, wherein the metal oxide is selected from silver oxide, copper oxide, gold oxide, zinc oxide, magnesium oxide, titanium oxide, chromium oxide and combinations thereof.

7. The article of claim 6, wherein the metal oxide is silver oxide.

8. The article of claim 7, wherein the silver oxide is Ag20.

9. The article of claim 8, wherein Ag+ release concentration of the article is more than 3.5 ppm,

10. The article of claim 9, wherein Ag+ release concentration of the article is more than 5 ppm.

1 1. The article of any of claim 10, wherein Ag+ release concentration of the article is more than 8 ppm.

12. The article of any of claims 1 to 1 1, wherein the metal oxide layer is formed by physical vapor deposition.

13. The article of any of claims 1 to 12, wherein the article exhibits a more than 4 log reduction of bacterial growth within 7 days.

14. The article of any of claims 1 to 13, wherein the article exhibits a more than 6 log reduction of bacterial growth within 7 days.

15. A method of use the article of claim 1, comprising of

providing the article of claim 1 ; and

applying the article to a subject;

wherein the article exhibits a more than 4 log reduction of bacterial growth within 7 days.