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1. (WO2015173664) PROCÉDÉ POUR LA PRÉPARATION DE(5S)-N-{3- [3,5-DIFLUORO-4- (4-HYDROXY -4-MÉTHOXYMÉTHYL-PIPÉRIDINE-1-YL)-PHÉNYL]-2-OXO-OXAZOLIDINE-5-YLMÉTHYL}-ACÉTAMIDE
Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

Claims

1. A process for preparation of a compound of Formula (I),

Formula (I)


said process comprising, reacting a compound of Formula (II) with a compound of Formula (III) in presence of a base and a polar aprotic solvent.

Formula (I II)


2. A process according to Claim 1 , wherein the base is selected from a group consisting of butyl lithium, sodium teri-butoxide, potassium teri-butoxide, lithium tert-butoxide or lithium diisopropylamide.

3. A process according to Claim 2, wherein the base is lithium teri-butoxide.

4. A process according to Claim 1 , wherein the polar aprotic solvent is selected from tetrahydrofuran, ethyl acetate, acetone, dimethylformamide, acetonitrile or dimethylsulfoxide.

5. A process according to Claim 4, wherein the polar aprotic solvent is tetrahydrofuran.

6. A process according to Claim 1, wherein compound of Formula (I) is obtained by reacting a compound of Formula (II) with a compound of Formula (III) in presence of an initiator.

7. A process according to Claim 6, wherein the initiator is selected from the group consisting methanol, ethanol or iso-propanol.

8. A process according to Claim 7, wherein the initiator is methanol.

9. A process according to Claim 1, wherein compound of Formula (I) is obtained by reacting a compound of Formula (II) with a compound of Formula (III) at a temperature of 10°C to 15°C.

10. A compound of Formula (I) having purity of at least about 97% as determined by HPLC.

11. A pharmaceutical composition comprising a compound of Formula (I) according to Claim 10.

12. A process for preparation of a compound of Formula (I),

Formula (I)


said process comprising, reacting a compound of Formula (II) with a compound of Formula (III) in presence of lithium feri-butoxide, tetrahydrofuran and methanol at a temperature of 10°C to 15°C.