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1. WO2014022792 - DISPOSITIF DE DIAGNOSTIC, DISPOSITIF THÉRAPEUTIQUE, ET LEURS UTILISATIONS

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

WHAT IS CLAIMED IS:

1. A photodiagnostic device to detect differences between healthy and abnormal cervical tissue, comprising:

a laser light source adapted for illumination of the cervical tissue;

a heat dissipation system to regulate the temperature of the light source;

a lens to collimate light from the light source;

an optic having a light pathway;

a light filter attached to the light pathway to direct the light from the lens to an end of the light pathway toward the cervical tissue; and

a light filter attached to the light pathway adapted to separate a spectral region of light from a fluorescence of light reflected by the cervical tissue.

2. The photodiagnostic device of claim 1, wherein the photodiagnostic device is hand held.

3. The photodiagnostic device of claim 1, wherein the light filter is a high pass filter.

4. The photodiagnostic device of claim 1, wherein the lens to collimate light includes a first lens and a second lens adapted to generate a light beam approximately 20 mm in diameter.

5. A photodynamic treatment device, comprising:

a light source;

a heat dissipation system to regulate the temperature of the light source;

a light guide adapted for vaginal insertion and to direct light generated by the light source to cervical tissue; and

a light protector attached to a distal end of the light guide adapted to surround the cervical tissue.

6. The photodynamic treatment device of claim 5, wherein the device produces an illumination area of approximately 20 mm in diameter.

7. The photodynamic treatment device of claim 5, further comprising:

a protective sleeve surrounding the light guide, the protective sleeve adapted for vaginal insertion; and

a ring provided between the light guide and the protective sleeve, adapted to center the protective sleeve on the light guide and to provide a biological barrier between the cervical tissue and the light source.

8. A photodiagnostic and photodynamic treatment device, comprising:

a photodiagnostic component, including a laser light source, a lens, and a light filter, adapted to generate and direct a first wavelength of light toward cervical tissue and to separate a spectral region of light from a fluorescence of light reflected by the cervical tissue;

a photodynamic treatment component, including a second light source and a light guide, adapted to generate light at a second wavelength and to direct the second wavelength of light onto the cervical tissue; and

a control component attached to the photodiagnostic component and the photodynamic treatment component providing power to the photodiagnostic component and the photodynamic treatment component and controlling activation of the laser light source and the second light source.

9. The photodiagnostic and photodynamic treatment device of claim 8, wherein the photodiagnostic component is hand held.

10. The photodiagnostic and photodynamic treatment device of claim 8, wherein the light filter is a high pass filter.

1 1. The photodiagnostic and photodynamic treatment device of claim 8, wherein the laser light source generates a light beam approximately 20 mm in diameter.

12. The photodiagnostic and photodynamic treatment device of claim 8, wherein the second light source generates a light beam approximately 20 mm in diameter.

13. The photodiagnostic and photodynamic treatment device of claim 8, wherein the light guide is adapted for vaginal insertion.

14. A method for detecting autofluorescence of abnormal cervical tissue, comprising: generating excitation light from a laser light source;

directing the excitation light toward cervical tissue;

receiving reflected excitation light and fluorescent light from the cervical tissue and passing the reflected light and the fluorescent light through a light filter to separate the reflected light from the fluorescent light; and

viewing the fluorescent light of abnormal cervical tissue.

15. The method of claim 14, wherein the light source and the light filter are incorporated into a hand held photodiagnostic device.

16. A method for treating cervical tissue using the device of claim 5, the cervical tissue having a photosensitizer compound disposed thereon, comprising:

selecting an appropriate dose of light energy;

generating a light emission with the light source; and

directing the light emission through a light guide to the cervical tissue for a selected period of time to deliver the selected dose of light energy.

17. The method of claim 16, wherein an area illuminated by the light emission is approximately 20 mm in diameter.

18. A method of diagnosing and treating abnormal cervical tissue, comprising:

analyzing cervical tissue by generating a laser light emission, directing the light emission toward the cervical tissue, passing the light emission through a light filter, and viewing the fluorescence of the cervical tissue to detect the presence of abnormal cervical tissue;

treating the abnormal cervical tissue having a photosensitizer compound disposed thereon by generating a second light emission and directing the second light emission

toward the cervical tissue to deliver a selected dose of light energy to destroy the abnormal cervical tissue.

19. The method of claim 18, further comprising:

after treating the abnormal cervical tissue, analyzing the cervical tissue by generating a second laser light emission, directing the light emission toward the cervical tissue, passing the light emission through a light filter, and viewing the fluorescence of the cervical tissue to detect the presence or absence of abnormal cervical tissue.

20. A method of diagnosing abnormal cervical tissue, comprising:

generating a laser light emission;

directing the light emission toward cervical tissue having a photosensitizer compound disposed thereon;

passing the light emission through a light filter; and

viewing the fluorescence of the cervical tissue.