Traitement en cours

Veuillez attendre...

Paramétrages

Paramétrages

Aller à Demande

1. WO2013048584 - PROMÉDICAMENTS DANS LE TRAITEMENT D'INFECTIONS MICROBIENNES

Numéro de publication WO/2013/048584
Date de publication 04.04.2013
N° de la demande internationale PCT/US2012/039371
Date du dépôt international 24.05.2012
CIB
A61P 31/00 2006.1
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
PACTIVITÉ THÉRAPEUTIQUE SPÉCIFIQUE DE COMPOSÉS CHIMIQUES OU DE PRÉPARATIONS MÉDICINALES
31Agents anti-infectieux, c. à d. antibiotiques, antiseptiques, chimiothérapeutiques
CPC
A61K 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
A61K 31/341
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
341not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/345
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
345Nitrofurans
A61K 31/47
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Déposants
  • NORTHEASTERN UNIVERSITY [US]/[US] (AllExceptUS)
  • LEWIS, Kim [US]/[US] (UsOnly)
  • FLECK, Laura [US]/[US] (UsOnly)
  • CASADEI, Gabriele [IT]/[IT] (UsOnly)
Inventeurs
  • LEWIS, Kim
  • FLECK, Laura
  • CASADEI, Gabriele
Mandataires
  • SCOZZAFAVA, Mary Rose
Données relatives à la priorité
61/489,37024.05.2011US
Langue de publication Anglais (en)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) PRODRUGS FOR TREATING MICROBIAL INFECTIONS
(FR) PROMÉDICAMENTS DANS LE TRAITEMENT D'INFECTIONS MICROBIENNES
Abrégé
(EN) Disclosed are methods of inhibiting the growth of pathogens using prodrug compounds as described herein. Also disclosed are methods of treating microbial infections using such compounds. Prodrugs are able to diffuse into the cell where they are converted into a reactive compound by bacterial-specific enzymes. The activated prodrug then covalently binds to multiple targets, creating an irreversible diffusion sink within the cell.
(FR) La présente invention concerne des procédés d'inhibition de la croissance d'agents pathogènes au moyen de composés de promédicaments. L'invention porte également sur des méthodes de traitement d'infections au moyen de ces composés.
Documents de brevet associés
Dernières données bibliographiques dont dispose le Bureau international