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1. WO2010023383 - NOUVEAU PROCEDE DE RESOLUTION DES ENANTIOMERES DU (3,4- DIMETHOXY-BICYCLO[4.2.0]OCTA-13,5-TRIEN-7-YL)NITRILE ET APPLICATION A LA SYNTHESE DE L'IVABRADINE

Numéro de publication WO/2010/023383
Date de publication 04.03.2010
N° de la demande internationale PCT/FR2009/001036
Date du dépôt international 27.08.2009
CIB
C07D 223/16 2006.01
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
DCOMPOSÉS HÉTÉROCYCLIQUES
223Composés hétérocycliques contenant des cycles à sept chaînons ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle
14condensés avec des carbocycles ou avec des systèmes carbocycliques
16Benzazépines; Benzazépines hydrogénées
CPC
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
C07C 209/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
44by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
48by reduction of nitriles
C07C 253/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
253Preparation of carboxylic acid nitriles
30by reactions not involving the formation of cyano groups
C07C 255/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
255Carboxylic acid nitriles
45having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
47to carbon atoms of rings being part of condensed ring systems
C07D 223/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
223Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
02not condensed with other rings
06with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
08Oxygen atoms
10attached in position 2
C07D 223/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
223Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
14condensed with carbocyclic rings or ring systems
16Benzazepines; Hydrogenated benzazepines
Déposants
  • LES LABORATOIRES SERVIER [FR]/[FR] (AllExceptUS)
  • LERESTIF, Jean-Michel [FR]/[FR] (UsOnly)
  • LECOUVE, Jean-Pierre [FR]/[FR] (UsOnly)
  • DRON, Daniel [FR]/[FR] (UsOnly)
  • GOJON, Eric [FR]/[FR] (UsOnly)
  • PHAN, Maryse [FR]/[FR] (UsOnly)
Inventeurs
  • LERESTIF, Jean-Michel
  • LECOUVE, Jean-Pierre
  • DRON, Daniel
  • GOJON, Eric
  • PHAN, Maryse
Représentant commun
  • LES LABORATOIRES SERVIER [FR]/[FR]
Données relatives à la priorité
080475529.08.2008FR
Langue de publication français (FR)
Langue de dépôt français (FR)
États désignés
Titre
(EN) NOVEL METHOD FOR RESOLVING THE ENANTIOMERS OF (3,4-DIMETHOXY­BICYCLO[4.2.0]OCTA-13,5-TRIEN-7-YL)NITRILE AND USE IN THE SYNTHESIS OF IVABRADINE
(FR) NOUVEAU PROCEDE DE RESOLUTION DES ENANTIOMERES DU (3,4- DIMETHOXY-BICYCLO[4.2.0]OCTA-13,5-TRIEN-7-YL)NITRILE ET APPLICATION A LA SYNTHESE DE L'IVABRADINE
Abrégé
(EN)
Method for optical resolution of the compound of formula (I): by chiral chromatography. Use in the synthesis of ivabradine, of addition salts thereof with a pharmaceutically acceptable acid and of hydrates thereof.
(FR)
Procédé de résolution optique du composé de formule (I) par chromatographie chirale. Application à la synthèse de l'ivabradine, de ses sels d'addition à un acide pharmaceutiquement acceptable et de leurs hydrates.
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