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1. WO2008011499 - SYNTHÈSE DU (2S,5R)-5-ÉTHYNYL-1-{N-(4-MÉTHYL-1-(4-CARBOXY-PYRIDIN-2-YL)PIPÉRIDIN-4-YL)GLYCYL}PYRROLIDINE-2-CARBONITRILE

Numéro de publication WO/2008/011499
Date de publication 24.01.2008
N° de la demande internationale PCT/US2007/073850
Date du dépôt international 19.07.2007
CIB
C07D 401/14 2006.01
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
DCOMPOSÉS HÉTÉROCYCLIQUES
401Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote
14contenant au moins trois hétérocycles
A61K 31/4545 2006.01
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
31Préparations médicinales contenant des ingrédients actifs organiques 
33Composés hétérocycliques
395ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines
435ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle
44Pyridines non condensées; Leurs dérivés hydrogénés
445Pipéridines non condensées, p.ex. pipérocaïne
4523contenant d'autres systèmes hétérocycliques
4545contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p.ex. pipampérone, anabasine
A61P 3/10 2006.01
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
PACTIVITÉ THÉRAPEUTIQUE SPÉCIFIQUE DE COMPOSÉS CHIMIQUES OU DE PRÉPARATIONS MÉDICINALES
3Médicaments pour le traitement des troubles du métabolisme
08de l'homéostase du glucose
10de l'hyperglycémie, p.ex. antidiabétiques
CPC
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
C07D 207/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 213/803
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78Carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals
79Acids; Esters
803Processes of preparation
C07D 401/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07F 7/0803
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7Compounds containing elements of Groups 4 or 14 of the Periodic System
02Silicon compounds
08Compounds having one or more C—Si linkages
0803Compounds with Si-C or Si-Si linkages
Déposants
  • ABBOTT LABORATORIES [US]/[US] (AllExceptUS)
  • MCDERMOTT, Todd, S. [US]/[US] (UsOnly)
  • WAGAW, Seble, H. [US]/[US] (UsOnly)
  • ENGSTROM, Kenneth, M. [US]/[US] (UsOnly)
  • GANDARILLA, Jorge [US]/[US] (UsOnly)
  • KRUGER, Albert [US]/[US] (UsOnly)
  • ROZEMA, Michael, J. [US]/[US] (UsOnly)
  • FICKES, Michael, G. [US]/[US] (UsOnly)
  • WITTENBERGER, Steven, J. [US]/[US] (UsOnly)
  • BHAGAVATULA, Lakshmi [US]/[US] (UsOnly)
  • BORCHARDT, Thomas, B. [US]/[US] (UsOnly)
Inventeurs
  • MCDERMOTT, Todd, S.
  • WAGAW, Seble, H.
  • ENGSTROM, Kenneth, M.
  • GANDARILLA, Jorge
  • KRUGER, Albert
  • ROZEMA, Michael, J.
  • FICKES, Michael, G.
  • WITTENBERGER, Steven, J.
  • BHAGAVATULA, Lakshmi
  • BORCHARDT, Thomas, B.
Mandataires
  • PARIAL, Andrew M.
Données relatives à la priorité
60/807,90120.07.2006US
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) SYNTHESIS OF (2S,5R)-5-ETHYNYL-1-{N-(4-METHYL-1-(4-CARBOXY-PYRIDIN-2-YL)PIPERIDIN-4-YL)GLYCYL}PYRROLIDINE-2-CARBONITRILE
(FR) SYNTHÈSE DU (2S,5R)-5-ÉTHYNYL-1-{N-(4-MÉTHYL-1-(4-CARBOXY-PYRIDIN-2-YL)PIPÉRIDIN-4-YL)GLYCYL}PYRROLIDINE-2-CARBONITRILE
Abrégé
(EN)
A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.
(FR)
La présente invention concerne, d'une part un procédé de fabrication du (2S,5R)-5-éthynyl-1-{N-(4-méthyl-1-(4-carboxy-pyridin-2-yl)pipéridin-4-yl)glycyl}pyrrolidine-2-carbonitrile et de certains de ses sels, et d'autre part des intermédiaires utilisés pour ce procédé.
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