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Paramétrages

1. WO2007149392 - SELS D'AMMONIUM MONOQUATERNAIRES ET PROCÉDÉS DESTINÉS À MODULER LES RÉCEPTEURS D'ACÉTYLCHOLINE NICOTINIQUES NEURONAUX

Numéro de publication WO/2007/149392
Date de publication 27.12.2007
N° de la demande internationale PCT/US2007/014192
Date du dépôt international 15.06.2007
CIB
A61K 31/44 2006.01
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
31Préparations médicinales contenant des ingrédients actifs organiques 
33Composés hétérocycliques
395ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines
435ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle
44Pyridines non condensées; Leurs dérivés hydrogénés
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
C07C 17/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
17Preparation of halogenated hydrocarbons
093by replacement by halogens
16of hydroxyl groups
C07D 213/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
16containing only one pyridine ring
20Quaternary compounds thereof
C07D 213/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24with substituted hydrocarbon radicals attached to ring carbon atoms
28Radicals substituted by singly-bound oxygen or sulfur atoms
30Oxygen atoms
C07D 215/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
04with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
10Quaternary compounds
C07D 217/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
02with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
10Quaternary compounds
Déposants
  • UNIVERSITY OF KENTUCKY [US/US]; A144 ASTeCC Bldg. Lexington, Kentucky 40536, US (AllExceptUS)
  • CROOKS, Peter [GB/US]; US (UsOnly)
  • DWOSKIN, Linda, P. [US/US]; US (UsOnly)
  • ZHENG, Guangrong [CN/US]; US (UsOnly)
  • SUMITHRAN, Sangeetha [IN/US]; US (UsOnly)
  • ZHENG, Zhenfa [CN/US]; US (UsOnly)
Inventeurs
  • CROOKS, Peter; US
  • DWOSKIN, Linda, P.; US
  • ZHENG, Guangrong; US
  • SUMITHRAN, Sangeetha; US
  • ZHENG, Zhenfa; US
Mandataires
  • EKSTROM, Richard, C.; Buchanan Ingersoll & Rooney PC P.O. Box 1404 Alexandria, VA 22313, US
Données relatives à la priorité
60/814,42316.06.2006US
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) MONO QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
(FR) SELS D'AMMONIUM MONOQUATERNAIRES ET PROCÉDÉS DESTINÉS À MODULER LES RÉCEPTEURS D'ACÉTYLCHOLINE NICOTINIQUES NEURONAUX
Abrégé
(EN)
Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
(FR)
La présente invention concerne des composés d'ammonium monoquaternaires qui sont des modulateurs des récepteurs d'acétylcholine nicotiniques. L'invention concerne en outre des procédés d'utilisation des composés pour la modulation de la fonction des récepteurs d'acétylcholine nicotiniques, ainsi que pour la prévention et/ou le traitement de troubles du système nerveux central, d'une consommation et/ou d'un abus d'alcool ou d'autres drogues, et de troubles du tractus gastro-intestinal.
Également publié en tant que
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