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1. WO2005001023 - PROCEDE ET COMPLEXES PORTEURS PERMETTANT D'ADMINISTRER DES MOLECULES A DES CELLULES

Numéro de publication WO/2005/001023
Date de publication 06.01.2005
N° de la demande internationale PCT/US2004/013772
Date du dépôt international 03.05.2004
CIB
C07K 5/00 2006.01
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
KPEPTIDES
5Peptides ayant jusqu'à quatre amino-acides dans une séquence entièrement déterminée; Leurs dérivés
CPC
A61K 31/713
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61K 38/47
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
47acting on glycosyl compounds (3.2), e.g. cellulases, lactases
A61K 47/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 47/645
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Déposants
  • CORNELL RESEARCH FOUNDATION, INC. [US/US]; 20 Thornwood Drive Ithaca, NY 14850, US (AllExceptUS)
  • SZETO, Hazel [US/US]; US (UsOnly)
  • ZHAO, Kesheng [CN/US]; US (UsOnly)
  • BIRK, Alex, V. [US/US]; US (UsOnly)
  • ROBERTSON, Hugh, D. [US/US]; US (UsOnly)
Inventeurs
  • SZETO, Hazel; US
  • ZHAO, Kesheng; US
  • BIRK, Alex, V.; US
  • ROBERTSON, Hugh, D.; US
Mandataires
  • FEIT, Irving, N. ; Hoffmann & Baron, LLP 6900 Jericho Turnpike Syosset, NY 11791, US
Données relatives à la priorité
60/467,51601.05.2003US
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) METHOD AND CARRIER COMPLEXES FOR DELIVERING MOLECULES TO CELLS
(FR) PROCEDE ET COMPLEXES PORTEURS PERMETTANT D'ADMINISTRER DES MOLECULES A DES CELLULES
Abrégé
(EN)
The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
(FR)
L'invention concerne des complexes porteurs et des procédés permettant d'administrer des molécules à des cellules. Les complexes porteurs comprennent une molécule et un peptide cationique aromatique selon l'invention. Dans un mode de réalisation, le procédé d'administration d'une molécule à une cellule consiste à mettre en contact la cellule avec un complexe porteur. Dans un autre mode de réalisation, le procédé d'administration d'une molécule à une cellule consiste à mettre en contact la cellule avec une molécule et un peptide cationique aromatique.
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