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1. WO2005000845 - DERIVES BICYCLIQUES UTILISES EN TANT QU'ANTAGONISTES DES RECEPTEURS NK-1 ET NK-2

Numéro de publication WO/2005/000845
Date de publication 06.01.2005
N° de la demande internationale PCT/EP2004/051210
Date du dépôt international 23.06.2004
CIB
A61K 31/4375 2006.01
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
31Préparations médicinales contenant des ingrédients actifs organiques 
33Composés hétérocycliques
395ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines
435ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle
4353condensés en ortho ou en péri avec des systèmes hétérocycliques
4375le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p.ex. quinolizines, naphtyridines, berbérine, vincamine
CPC
A61K 31/4375
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4375the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
C07D 211/58
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
36with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56Nitrogen atoms
58attached in position 4
C07D 295/155
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04with substituted hydrocarbon radicals attached to ring nitrogen atoms
14substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
155with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Déposants
  • NIKEM RESEARCH S.R.L. [IT/IT]; Via Zambeletti 25 I-20021 Baranzate di Bollate, IT (AllExceptUS)
  • GIARDINA, Giuseppe Arnaldo Maria [IT/IT]; IT (UsOnly)
  • GAGLIARDI, Stefania [IT/IT]; IT (UsOnly)
Inventeurs
  • GIARDINA, Giuseppe Arnaldo Maria; IT
  • GAGLIARDI, Stefania; IT
Mandataires
  • GERVASI, Gemma; NOTARBARTOLO & GERVASI S.p.A. Corso di Porta Vittoria 9 I-20122 MILAN, IT
Données relatives à la priorité
MI2003A00129225.06.2003IT
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) BICYCLIC DERIVATIVES AS NK-1 AND NK-2 ANTAGONISTS
(FR) DERIVES BICYCLIQUES UTILISES EN TANT QU'ANTAGONISTES DES RECEPTEURS NK-1 ET NK-2
Abrégé
(EN)
Novel derivatives of formula (1) endowed with antagonistic activity towards the neurokinin-1 (NK-1) and.neurokinin-2 (NK-2) receptors and the preparation procedure thereof are described. The compounds of the invention are useful in the prevention and/or treatment of diseases dependent upon the stimulation of the NK-1 and NK-2 receptors. Formula (I) or a salt and/or solvate thereof, wherein Z is N or CH; represents on the condition that when A is Z does not represent N.
(FR)
L'invention concerne des nouveaux dérivés de formule (1) qui présentent une activité antagoniste envers les récepteurs neurokinine 1 (NK-1) et neurokinine 2 (NK-2), ainsi que le procédé de préparation de ceux-ci. Ces composés sont utiles dans la prévention et/ou le traitement des maladies associées à la stimulation des récepteurs NK-1 et NK-2.
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