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1. WO2005000330 - AGENTS ANGIOGENIQUES PROVENANT D'EXTRAITS VEGETAUX, ACIDE GALLIQUE ET SES DERIVES

Numéro de publication WO/2005/000330
Date de publication 06.01.2005
N° de la demande internationale PCT/US2004/016647
Date du dépôt international 27.05.2004
CIB
A61K 31/192 2006.01
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
31Préparations médicinales contenant des ingrédients actifs organiques 
185Acides; Leurs anhydrides, halogénures ou sels, p.ex. acides du soufre, acides imidiques, hydrazoniques ou hydroximiques
19Acides carboxyliques, p.ex. acide valproïque
192ayant des groupes aromatiques, p.ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
CPC
A61K 31/192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
192having aromatic groups, e.g. sulindac, 2-arylpropionic acids, ethacrynic acid
A61K 31/454
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/7024
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7024Esters of saccharides
A61K 36/40
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
40Cornaceae (Dogwood family)
A61K 36/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
44Ebenaceae (Ebony family), e.g. persimmon
A61K 36/708
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
70Polygonaceae (Buckwheat family), e.g. spineflower or dock
708Rheum (rhubarb)
Déposants
  • BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE [US/US]; Louisiana State University Suite 115, System Building 3810 West Lakeshore Baton Rouge, LA 70808, US (AllExceptUS)
  • GREENWAY, Frank, L. [US/US]; US (UsOnly)
  • LIU, Zhijun [US/US]; US (UsOnly)
  • WOLTERING, Eugene, A. [US/US]; US (UsOnly)
Inventeurs
  • GREENWAY, Frank, L.; US
  • LIU, Zhijun; US
  • WOLTERING, Eugene, A.; US
Mandataires
  • DAVIS, Bonnie, J.; Taylor, Porter, Brooks & Phillips L.L.P. P.O. Box 2471 Baton Rouge, LA 70821-2471, US
Données relatives à la priorité
60/473,80628.05.2003US
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) ANGIOGENIC AGENTS FROM PLANT EXTRACTS, GALLIC ACID, AND DERIVATIVES
(FR) AGENTS ANGIOGENIQUES PROVENANT D'EXTRAITS VEGETAUX, ACIDE GALLIQUE ET SES DERIVES
Abrégé
(EN)
An extract of Chinese blackberry (Rubus suavissimus) has been found to inhibit angiogenesis, and two active fractions isolated. Gallic acid was shown to be one of the active anti-angiogenic compounds by an in vitro human angiogenesis model. Aqueous extracts from other plants either known or found to have gallic acid were also found to have anti-angiogenic activity. Various derivatives of gallic acid were found to inhibit angiogenesis. The extract from Chinese blackberry also slowed the growth of a pancreatic tumor and of corneal neovascularization in rats. Extracts from pomegranate were shown to inhibit angiogenesis in fat tissue. Extracts from Rubus spp, and other plants with gallic acid, and gallic acid and its derivatives will be useful for treating various diseases associated with neovascularization, including diabetic retinopathy, psoriasis, tumors, obesity, cancer, rheumatoid arthritis, etc.
(FR)
L'invention concerne un extrait de mûre chinoise (Rubus suavissimus) permettant d'inhiber l'angiogenèse, et deux fractions isolées. L'acide gallique est un des composés anti-angiogéniques dans un modèle d'angiogenèse humain in vitro. Des extraits aqueux d'autres plantes comprenant de l'acide gallique présentent une activité anti-angiogénique. De nombreux dérivés d'acide gallique permettent d'inhiber l'angiogenèse. L'extrait de mûre chinoise diminue également la croissance d'une tumeur pancréatique et la néovascularisation cornéenne des rats. Des extraits de grenade permettent d'inhiber l'angiogenèse dans des tissus graisseux. Des extraits de Rubus spp, et d'autres plantes à acide gallique, de l'acide gallique et ses dérivés sont utilisés pour traiter de nombreuses maladies associées à la néovascularisation, notamment la rétinopathie diabétique, le psoriasis, les tumeurs, l'obésité, le cancer, l'arthrite rhumatoïde, etc.
Également publié en tant que
GB0515097
US2007031332
Dernières données bibliographiques dont dispose le Bureau international