Traitement en cours

Veuillez attendre...

Paramétrages

Paramétrages

Aller à Demande

1. WO2004098671 - PROCEDES DE PRODUCTION DE REVETEMENTS POLYMERES POUR LA LIBERATION D'AGENT THERAPEUTIQUE

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

IN THE CLAIMS:

1. A method for providing a therapeutic-agent-containing medical device comprising: (a) providing a reactive layer comprising a cross-linking agent on a medical device surface; and (b) applying a polymer-containing layer comprising a polymer and a therapeutic agent over said reactive layer, wherein said cross-linking agent interacts with said polymer to form a cross-linked polymeric region comprising said therapeutic agent.

2. The method of claim 1 , wherein said medical device is an implantable or insertable medical device.

3. The method of claim 1, wherein said medical device is selected from a catheter, a balloon, a cerebral aneurysm filler coil and an arterio-venous shunt.

4. The method of claim 1 , wherein said medical device is a stent.

5. The method of claim 4, wherein said device is a vascular stent.

6. The method of claim 1, wherein said crosslinking agent is an ionic crosslinking agent.

7. The method of claim 6, wherein said crosslinking agent is a cationic crosslinking agent.

8. The method of claim 7, wherein said polymer is a mono-valent poly-glycosamino- glycan polymer.

9. The method of claim 8, wherein said polymer is sodium alginate.

10. The method of claim 8, wherein said crosslinking agent comprises calcium cations.

11. The method of claim 1, wherein said crosslinking agent is a covalent crosslinking agent.

12. The method of claim 11, wherein said covalent crosslinking agent covalently bonds two amino acids.

13. The method of claim 12, wherein said covalent crosslinking agent is a
transglutaminase crosslinking agent.

14. The method of claim 1, wherein said polymer-containing layer further comprises water at the time of application.

15. The method of claim 1, wherein said polymer-containing layer is applied by spray coating.

16. The method of claim 1, wherein said polymer-containing layer is applied by stereo- lithographic deposition.

17. The method of claim 1, wherein said therapeutic agent comprises protein.

18. The method of claim 1, wherein said therapeutic agent comprises whole cells.

19. The method of claim 1, wherein said therapeutic agent comprises DNA.

20. The method of claim 19, wherein said therapeutic agent further comprises a vector for delivering said DNA.

21. The method of claim 20, wherein said vector is a viral vector.

22. The method of claim 18, wherein said therapeutic agent further comprises extracellular matrix components.