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1. WO2004098603 - UTILISATION D'ACIDES AMINOALCANEPHOSPHONIQUES SUBSTITUES POUR TRAITER LA SCLEROSE EN PLAQUES

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]

CLAIMS

1. The use of a compound of formula


wherein
R is hydroxy or (C1-4)alkyl,
R2 is (C1-4)alkyl
R3 is hydrogen, (CH) alkyl, fluorine, chlorine, bromine, trifluoromethyl, cyano or nitro, and
X is (C1-6)alkylene, (C1-6)alkylidene, (C1-6)alkylene(C3-6)cycloalkylene or
(C1-6)alkylene(C3-6)cycloalkylidene,
in free or in pharmaceutically acceptable salt form, for the treatment of multiple sclerosis and related demyelinating diseases.

The use according to claim 1 , wherein the compound of formula I is
{[(7-nitro-2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-5-ylmethyl)-amino]-methyl}- phosphonic acid, (R)-N-(2,3-dioxo-7-nitro-1 ,2,3,4-tetrahydroquinoxaline-5- ylmethyl)-α-(ethylamino)-ethyIphosphonic acid or (S)-N-(7-bromo-2,3-dioxo- 1,2,3,4-tetrahydroquinoxaline-5-ylmethyl)-α-aminoethylphosphonic acid, in free or pharmaceutically acceptable salt form.

A pharmaceutical composition which incorporates as active agent a compound of formula I according to claim 1 in free or pharmaceutically acceptable salt form, for use in the treatment of multiple sclerosis and related demyelinating diseases.

The use of a compound of formula I according to claim 1 , in free or
pharmaceutically acceptable salt form, for the manufacture of a pharmaceutical composition for the treatment of multiple sclerosis and related demyelinating diseases.

A method for the treatment of multiple sclerosis and related demyelinating diseases in a subject in need of such treatment, which comprises administering to said subject a therapeutically effective amount of a compound of formula I according to claim 1 in free or pharmaceutically acceptable salt form.