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1. WO2003004466 - SULFENATES COLORANTS UTILISES DANS LA DOUBLE PHOTOTHERAPIE

Numéro de publication WO/2003/004466
Date de publication 16.01.2003
N° de la demande internationale PCT/US2002/019184
Date du dépôt international 18.06.2002
Demande présentée en vertu du Chapitre 2 27.01.2003
CIB
A61K 41/00 2006.01
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
41Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
CPC
A61K 41/0033
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0028Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
0033Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
A61K 41/0057
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
A61K 41/0071
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
0071PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
A61K 49/0032
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
0032Methine dyes, e.g. cyanine dyes
A61K 49/0056
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
005characterised by the carrier molecule carrying the fluorescent agent
0056Peptides, proteins, polyamino acids
C09B 23/083
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
23Methine or polymethine dyes, e.g. cyanine dyes
02the polymethine chain containing an odd number of >CH- ; or >C[alkyl]-; groups
08more than three >CH- groups, e.g. polycarbocyanines
083five >CH- groups
Déposants
  • MALLINCKRODT INC. [US/US]; 675 McDonnell Boulevard P.O. Box 5840 St. Louis, MO 63134, US (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW)
  • RAJAGOPALAN, Raghavan [US/US]; US (UsOnly)
  • ACHILEFU, Samuel, I. [NG/US]; US (UsOnly)
  • BUGAJ, Joseph, E. [US/US]; US (UsOnly)
  • DORSHOW, Richard, B. [US/US]; US (UsOnly)
Inventeurs
  • RAJAGOPALAN, Raghavan; US
  • ACHILEFU, Samuel, I.; US
  • BUGAJ, Joseph, E.; US
  • DORSHOW, Richard, B.; US
Mandataires
  • CHEATHAM, Tim A.; 675 McDonnell Boulevard P.O. Box 5840 St. Louis, MO 63134, US
Données relatives à la priorité
09/898,80903.07.2001US
Langue de publication anglais (EN)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) DYE-SULFENATES FOR DUAL PHOTOTHERAPY
(FR) SULFENATES COLORANTS UTILISES DANS LA DOUBLE PHOTOTHERAPIE
Abrégé
(EN)
The present invention discloses dye-sulfenate derivatives and their bioconjugates for dual phototherapy of tumors and other lesions. The compounds of the present invention may contain either a mixture of type 1 and type 2 agents or a single entity that integrates both units in the same molecules. The compounds are designed to produce both type 1 and type 2 phototherapeutic effect at once using dual wavelength light source that will produce singlet oxygen and free radicals at the lesion of interest.
(FR)
L'invention se rapporte à des dérivés de sulfénate colorant et à leurs bioconjugués utilisés dans la photothérapie des tumeurs et autres lésions. Les composés selon l'invention peuvent contenir soit un mélange d'agents de Type 1 et de Type 2 ou une seule entité qui comprend les deux unités dans les mêmes molécules. Ces composés sont utilisés afin de provoquer immédiatement des effets thérapeutiques de Type 1 et de Type 2 au moyen d'une source de lumière à longueur d'onde qui produira un oxygène singulet et des radicaux libres sur la lésion concernée.
Également publié en tant que
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