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1. WO1988003794 - AGENT POUR TRAITEMENT EXTERNE D'ANIMAUX DOMESTIQUES

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[ EN ]
AGENT FOR EXTERNAL TREATMENT OF DOMESTIC ANIMALS

Field of the invention
The invention relates to an agent for treating the skin of domestic animals, especially cows, and in particular the udder and teats thereof.
Background of the invention
Within the highly rationalized animal husbandry of today, especially cattle breeding, with stringent demands on the products yielded thereby, it is of the utmost importance that the domestic animals be kept in good shape and that infections and injuries be avoided and prevented.
In the case of cows, there is a special problem residing in that the udder and the teats of the cows are subjected to heavy strains and that these zones easily become swollen and infected. This, in turn, may affect the milk produced which may be contaminated with bacteria and thus declared unfit. Even if there are medicines for curing such diseases relatively quickly, the loss of milk production may however be-come perceptible since, during an infection and some time after it, the cow must go dry. It is therefore desirable to take steps to avoid and prevent the occurrence of such injuries and infections.
Hitherto, several different preparations have been used for different situations in connection with the treatment of the udders of milking cows, such as a disinfectant for destroying bacteria, an ointment for treating swellings and an ointment for treating chaps and wounds. These ointments are however relatively difficult to apply and also often leave a smeary surface.
Description of the invention
The present invention relates to an agent for treating the skin of domestic animals, especially cows, both for prophylactic reasons and as a continuous cure. The invented agent is in the form of a homogeneous liquid composition of the following composition, expressed in per cent by volume:
15-30% soft soap
4-10% peanut oil
4-10% spirit of camphor
1-5% spirit of vinegar
30-50% lower aliphatic alcohol
20-40% water.
The term "soft soap" as used in this context
relates to ordinary commercial yellow soap substantially containing tall oil, fatty acids and caustic soda. The term "lower aliphatic alcohol" relates to an alcohol having 1-10 carbon atoms, preferably 1-6 car-bon atoms, especially monoalcohols, with special preference for isopropanol . The term "spirit of camphor" relates to an at least 20% solution of camphor in
alcohol, which alcohol preferably is the same as the alcohol included in the composition.
In previously known compositions . intended to
be applied to the skin of humans or animals, lower alcohols in the form of solvents are a commonly used component, as are different oils and fats used as
consistency and softening agents. Further, camphor is a known constituent In liniments and thus known in skin-treating contexts. Soap of different kinds has hitherto been used in compositions to be applied to the skin, but there is no prior disclosure of the use of common commercial soft soap.
For the use of soft soap and alcohol, see CH-A
168,879; for the use of spirit of vinegar and alcohol, see H. Enell, H. Thedenius and R. Luhr, Pharmaca Composite, second edition, C & E Gernandts Fδrlags Aktiebolag, Stockholm 1896, pp. 218 and 405; for the use of peanut oil, see Ullmanns Encyklopadie der technischen Chemie, dritte Auflage, 10. Band, pp. 683 and 693; and for the use of camphor, see SE-A 120,573.

A composition consisting of the majority or all of the components included in the agent of the present invention is however not previously known. Thus, the invention provides a new agent which has been found to produce an effect which it has not been possible to foresee on the basis of the individual components included, which when used together in the agent of the invention have proved to coact in a manner to produce an unexpected and valuable effect.
The agent now invented is intended for external application to domestic animals, especially cows, and serves both to destroy bacteria and to soften the skin. When the agent is applied to the udder and teats of cows, the blood circulation through these parts increases, so that swellings are caused to disappear and the skin is softened. An efficient way of treating a cow is, after each milking event, to apply the inventive agent, e.g. by means of a spray device, to the teats and, if required, also to the udder of the cow. In this manner, it is possible to counteract and prevent the occurrence of swellings, skin trouble and infections, whereby to considerably facilitate the milking operation and improve the conditions for a reduced cell content, i.e. a low bac-teria count, in the milk.
The invented agent can also be used for treating domestic animals other than cows in cases where the skin of the animals are subjected to strains of different kinds.
The agent according to the invention has a preferred composition as indicated below, expressed in per cent by volume:
18-25% soft soap
5-8% peanut oil
5-8% spirit of camphor
1.5-3% spirit of vinegar 35-45% lower aliphatic alcohol
22-30% water.
A particularly preferred embodiment of the invention has the following composition:
20% soft soap
6% peanut oil
6% spirit of camphor
2% spirit of vinegar
40% isopropanol
26% water.
The agent according to the invention is prepared by successively mixing the components with each other at room temperature and in a certain, suitable order as stated in Example 1 below.
The functions of the different components of the composition have been studied by successively excluding each one of the components. The following conclusions have been drawn:
a) §2f_:__i2§2 ~ This component has both a cleansing effect and a swelling-reducing and swelling-inhibiting effect by Increasing blood circulation.
b) Peanut_oil - This component both gives the composition a suitable consistency and has an emollient and protective effect. Without this component, the other relatively aggressive components of the agent would tend to burn the teats of the treated animal .
c) §p_irit_of_camphor - This component has a swelling-reducing and swelling-inhibiting effect, but also makes the composition coherent and adherent. When spraying an agent without any spirit of camphor included, the agent will soon trickle off the udder and drop onto the ground, whereas an agent containing spirit of camphor will adherently flow along the sur-face of the udder.
°^ _^i£2_12i ~ This component has a bactericidal effect.

e) Water is used in suitable amounts to avoid having an excessive per cent by volume of alcohol.
f) §p_irit_of_vinegar - This component also has a bactericidal effect, but additionally seems to have an interlinking and fortifying effect on the functions of the other components. In tests without spirit of vinegar included, none of the surprisingly good effects regarding skin softening and swelling reduction as otherwise found when using the agent was now achieved to any noticeable extent.
The agent according to the invention also means a considerable simplification for the treatment and cure of the udders of milking cows. Hitherto, it has been necessary to use several different preparations for different situations, such as one ointment for swellings, one ointment for wounds and chaps, and one iodine preparation for destroying bacteria and obturating the teat canals for avoiding infections.
With the invention, all these functions are obtained in one and the same preparation which, moreover, is easier to apply since it is in spray form and is rapidly absorbed into the skin and leaves no smeary layer as in the case of ointments .
It may also be pointed out that the present agent has met with substantial success for preventing and palliating so-called summer sores. This is a disease afflicting summer cows with sensitive udders when in open pasture where the sun, in combination with dirt and mud which have clogged to the cow's skin, may cause injuries to the udder and the teats.
The invented agent has been tested for six months on stocks within a certain geographical area of Sweden. Very good results have been obtained as regards reduction of udder swellings in cows and, in sensitive cows, also inhibition of such swellings, as well as softening of the skin of the teats. Cows continuously treated with the agent have thus exhibited healthy udders and teats, been easy to milk and yielded milk with low cell content. The agent has also been tested on horses in some contexts where the skin has been subjected to strains, and good results have also been obtained in these cases. Further, tests have been
carried out, excluding certain components in the composition or replacing them with similar components, as reported in Examples 2 and 3 below. In these cases, a dramatically reduced effect, or almost no effect at all, was obtained. The agent according to the invention thus has a unique composition where the included components coact in an unexpected manner, producing a valuable effect.
Example 1
A batch of 5 1 of the agent was prepared in the following way:
10 dl of soft soap was admixed with 3 dl of peanut oil . 3 dl of spirit of camphor of a previously prepared solution, obtained by dissolving 1.5 kg of camphor in a small amount of isopropanol and diluting it with isopropanol to give a 20% solution, was then added.
To the resultant mixture was then added 1 dl of spirit of vinegar, whereupon 2 1 of isopropanol was admixed and the mixture diluted with 1.3 1 of water .
The thus prepared composition was then placed in a spray device. The composition can be sprayed
onto the teats of a cow after milking. If the udder of the cow seems strained, the composition can also be sprayed onto it after each milking event. If the udder is healthy, it is sufficient to spray it from
1-2 times a week up to once a day.
Example 2
A batch of the agent was prepared in the same manner as in Example 1, however with the exclusion of spirit of vinegar.
When using the agent on cows according to Example 1, practically none of the skin-softening and blood circu- lation-promoting effects obtained with the agent according to the invention were now observed, and swellings on the cows were not appreciably affected.
Example 3
A batch of the agent was prepared in the same manner as in Example 1, however replacing the soft soap with tall oil.
When using the agent on cows according to Example 1, an approximately equally low effect was obtained as in Example 2.