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1. WO1979000106 - PROCEDE DE PREPARATION DE COMPOSITIONS BIOLOGIQUES UTILISEES COMME CONTROLES-TEMOINS DANS LES ANALYSES DIAGNOSTIQUES

Numéro de publication WO/1979/000106
Date de publication 08.03.1979
N° de la demande internationale PCT/US1978/000069
Date du dépôt international 22.08.1978
CIB
G01N 33/96 2006.1
GPHYSIQUE
01MÉTROLOGIE; TESTS
NRECHERCHE OU ANALYSE DES MATÉRIAUX PAR DÉTERMINATION DE LEURS PROPRIÉTÉS CHIMIQUES OU PHYSIQUES
33Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes G01N1/-G01N31/146
48Matériau biologique, p.ex. sang, urine; Hémocytomètres
50Analyse chimique de matériau biologique, p.ex. de sang ou d'urine; Test par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligands; Test immunologique
96faisant intervenir un étalon de contrôle du sang ou du sérum
CPC
G01N 2496/05
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2496Reference solutions for assays of biological material
05containing blood cells or plasma
G01N 2496/80
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2496Reference solutions for assays of biological material
80Multi-analyte reference solutions containing cholesterol, glucose and the like
G01N 33/96
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
96involving blood or serum control standard
Y10T 436/103332
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
436Chemistry: analytical and immunological testing
10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
103332Bilirubin or uric acid standard or control
Y10T 436/104165
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
436Chemistry: analytical and immunological testing
10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
104165Lipid, cholesterol, or triglyceride standard or control
Y10T 436/104998
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
436Chemistry: analytical and immunological testing
10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
104998Glucose, ketone, nitrate standard or control
Déposants
Inventeurs
Données relatives à la priorité
82697322.08.1977US
Langue de publication Anglais (en)
Langue de dépôt anglais (EN)
États désignés
Titre
(EN) PROCESS FOR PREPARING BIOLOGICAL COMPOSITIONS FOR USE AS A REFERENCE CONTROL IN DIAGNOSTIC ANALYSIS
(FR) PROCEDE DE PREPARATION DE COMPOSITIONS BIOLOGIQUES UTILISEES COMME CONTROLES-TEMOINS DANS LES ANALYSES DIAGNOSTIQUES
Abrégé
(EN) The present disclosure is directed to the preparation of stable aqueous-containing biological compositions capable of use as liquid reference serum in diagnostic chemical analysis using multichannel automated analyzers and having improved storage stability and capable of storage in the liquid state for extended periods of time measured in weeks when stored at 2 to 8 C.; processes for preparing the reference serums and the process of automated analysis utilizing the improved reference serums. The subject materials are prepared by freezing the aqueous-containing labile biologicals rapidly at temperatures ranging from about -20 to about -30 C., removing from about 98 to 99 weight per cent of the water therefrom and storing same (as a dehydrated solid) at 2 to 8 C. until desired use. The dehydrated material is then reconstituted by dissolving it in a medium containing from about 20 to about 50 weight per cent of an alkylene polyol containing from 2 to 5 carbon atoms with the remainder being water. The thus reconstituted biological compositions can be stored in the liquid state at 2 to 8 C. for periods of 4 to 5 weeks or at -20 C. for months.
(FR) Procedes de preparation de serums temoins et d"analyse automatisee utilisant les serums temoins ameliores qui consistent en des compositions biologiques aqueuses stables pouvant etre utilisees comme serums temoins liquides dans les analyses chimiques diagnostiques ayant recours a des analyseurs automatiques a plusieurs canaux, lesdites compositions ayant une meilleure stabilite de conservation et susceptibles d"etre conservees a l"etat liquide pendant des periodes de temps prolongees equivalentes a plusieurs semaines lorsqu"elles sont conservees entre 2 C et 8 C. Les matieres en question sont preparees en congelant rapidement les substances biologiques labiles aqueuses a des temperatures allant de -20 C a -30 C environ, en enlevant de ces substances 98% a 99% en poids d"eau et en les conservant (sous forme d"un solide deshydrate) entre 2 C et 8 C, jusqu"a utilisation, Le materiau deshydrate est ensuite reconstitue en le dissolvant dans un milieu contenant entre 20% et 50% environ en poids d"un polyol d"alcoylene contenant de 2 a 5 atomes de carbone, l"eau constituant la balance. Les compositions biologiques ainsi reconstituees peuvent etre conservees a l"etat liquide entre 2 C et 8 C pendant des periodes de 4 a 5 semaines ou a 20 C pendant des mois.
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