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1. US20060141070 - Notoginseng saponin intravenous injection and the method for preparing this injection

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Claims

1. A saponins family of Radix notoginshen intravenous injection comprising:
(1) saponins family of Radix notoginshen with concentration of 0.1 mg -14.0 mg (Rgl);
(2) iso-osmotic solution with concentration of 7.5-9.5 mg/ml;
(3) pH stabilizer with a concentration of 0.1-0.5 mg/ml; and
(4) distilled water for injection as a solvent.
2. The injection according to claim 1, wherein the concentration of said saponins family of Radix notoginshen is 1.0-7.0 mg (Rgl)/ml.
3. The injection according to claim 2, wherein the concentration of said saponins family of Radix notoginshen is 1.0-3.5 mg (Rgl)/ml.
4. The injection according to claim 3, wherein the concentration of said saponins family of Radix notoginshen is 1.4 mg (Rgl)/ml.
5. The injection according to claim 1, wherein said iso-osmotic solution is sodium chloride, glucose, and sorbital.
6. The injection according to claim 1, 2, 3, or 4 wherein said iso-osmotic solution is sodium chloride.
7. The injection according to claim 6, wherein the concentration of said sodium chloride is 7.5-9.5 mg/ml.
8. The injection according to claim 7, wherein the concentration of said sodium chloride is 8.5 mg/ml.
9. The injection according to claim 1, 2, 3, or 4 wherein said pH stabilizer is sodium citrate, citrate, phosphate, and acetate.
10. The injection according to claim 9, wherein said pH stabilizer is sodium citrate.
11. The injection according to claim 10, wherein the concentration of said sodium citrate is 0.1-0.5 mg/ml.
12. The injection according to claim 11, wherein the concentration of said sodium citrate is 0.3 mg/ml.
13. A method for preparation of saponins family of Radix notoginshen intravenous injection comprising:
(1) diluting iso-osmotic solution is in distilled water to a concentration of 80-300 mg/ml, and filtering the same through active carbon;
(2) stirring saponins family of Radix notoginshen and dissolving it in the filtrate to a concentration of 0.1 mg-14.0 mg(Rgl)/ml;
(3) adding pH stabilizer to the filtrate to a concentration of 0.1-0.5 mg/ml; whereby the solution is filtered until clear, pasteurized, and packed; the resulting product being saponins family of Radix notoginshen intravenous injection.
14. The method according to claim 13, wherein the concentration of said saponins family of Radix notoginshen is 1.4 mg (Rgl)/ml.
15. The method according to claim 13, wherein said iso-osmotic solution is sodium chloride, and its concentration is 100-200 mg/ml.
16. The method according to claim 13, wherein said iso-osmotic solution is glucose, and its concentration is 50 mg/ml.
17. The method according to claim 13, wherein said pH stabilizer is sodium citrate, citrate, phosphate, and acetate, and its concentration is 0.3 mg/ml.