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1. US20070149584 - Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors

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Office États-Unis d'Amérique
Numéro de la demande 11177324
Date de la demande 11.07.2005
Numéro de publication 20070149584
Date de publication 22.06.2006
Numéro de délivrance 7385085
Date de délivrance 10.06.2008
Type de publication B2
CIB
C07C 237/00
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
CCOMPOSÉS ACYCLIQUES OU CARBOCYCLIQUES
237Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino
C07C 237/04
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
CCOMPOSÉS ACYCLIQUES OU CARBOCYCLIQUES
237Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino
02ayant les atomes de carbone des groupes carboxamide liés à des atomes de carbone acycliques du squelette carboné
04le squelette carboné étant acyclique et saturé
CPC
C07D 285/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
285Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
01Five-membered rings
02Thiadiazoles; Hydrogenated thiadiazoles
04not condensed with other rings
081,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
C07C 233/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
34having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
35with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
36having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
C07C 237/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
20the carbon skeleton containing six-membered aromatic rings
C07C 251/44
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
251Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
32Oximes
34with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
44with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
C07C 251/54
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
251Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
32Oximes
50having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
54of hydrocarbon radicals substituted by singly-bound oxygen atoms
C07C 251/84
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
251Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
72Hydrazones
84having doubly-bound carbon atoms of hydrazone groups being part of rings other than six-membered aromatic rings
Déposants Elan Pharmaceuticals, Inc.
Inventeurs John Varghese
Maillard Michel
Jagodzinska Barbara
Aquino Jose
Probst Gary
Tung Jay
Mandataires Finnegan, Henderson, Farabow, Garrett &; Dunner, L.L.P.
Données relatives à la priorité 60586207 09.07.2004 US
60608143 09.09.2004 US
60656873 01.03.2005 US
60681138 16.05.2005 US
Titre
(EN) Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors
Abrégé
(EN)

The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
Également publié en tant que
EP1773756
CA2573138
WO/2006/010095
JP2008505930
US20090042961
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