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1. SK20010699 - Eletriptan hydrobromide monohydrate, processes for its preparation and use, pharmaceutical composition containing thereof and process for preparing anhydrous eletriptan hydrobromide

Office
Slovaquie
Numéro de la demande 2001000699
Date de la demande 01.11.1999
Numéro de publication 20010699
Date de publication 07.01.2002
Numéro de délivrance 285774
Date de délivrance 02.08.2007
Type de publication B6
CIB
C07D 403/06
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
DCOMPOSÉS HÉTÉROCYCLIQUES
403Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe C07D401/180
02contenant deux hétérocycles
06liés par une chaîne carbonée ne contenant que des atomes de carbone aliphatiques
A61K 31/40
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
31Préparations médicinales contenant des ingrédients actifs organiques 
33Composés hétérocycliques
395ayant l'azote comme hétéro-atome d'un cycle, p.ex. guanéthidine ou rifamycines
40ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p.ex. sulpiride, succinimide, tolmétine, buflomédil
A61P 25/06
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
PACTIVITÉ THÉRAPEUTIQUE SPÉCIFIQUE DE COMPOSÉS CHIMIQUES OU DE PRÉPARATIONS MÉDICINALES
25Médicaments pour le traitement des troubles du système nerveux
06Agents antimigraineux
CPC
A61K 31/4045
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
A61P 1/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
08for nausea, cinetosis or vertigo; Antiemetics
A61P 1/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 9/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
12Antihypertensives
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
Déposants PFIZER INC.
Inventeurs DallmanChristopher Ian
OgilvieRonald James
Mandataires JUDr. Eva Busova, Advokatska kancelaria, Tobrucka 6, 811 02 Bratislava,Slovenska republika
Données relatives à la priorité 9825988.0 27.11.1998 GB
Titre
(EN) Eletriptan hydrobromide monohydrate, processes for its preparation and use, pharmaceutical composition containing thereof and process for preparing anhydrous eletriptan hydrobromide
(SK) Eletriptan hydrobromid monohydrát, spôsoby jeho prípravy a použitie, farmaceutická kompozícia s jeho obsahom a spôsob prípravy bezvodného eletriptan hydrobromidu
Abrégé
(EN)
In the present invention, there is disclosed eletriptan hydrobromide monohydrate of the general formula (I) and a pharmaceutical composition including eletriptan hydrobromide, its use for the manufacture of a medicament for treating a disease or condition for which a selective agonist of a 5-HT1 receptor is indicated. Disclosed are also processes for preparing the above described composition comprising a) treatment of a solution of eletriptan in water, or in an organic solvent containing a sufficient amount of water to facilitate formation of the required monohydrate, with hydrogen bromide or a source thereof or b) crystallization of any other form of eletriptan hydrobromide, or a mixture thereof, from water, or from an organic solvent containing a sufficient amount of water to facilitate formation of the required monohydrate, a process for preparing anhydrous eletriptan hydrobromide which comprises dehydration of eletriptan hydrobromide monohydrate.

(SK)
Opisuje sa eletriptan hydrobromid monohydrát vzorca (I) a farmaceutická kompozícia s jeho obsahom, jeho použitie na prípravu liečiva určeného na liečenie choroby alebo stavu, kde je indikovaný selektívny agonista 5-HT1 receptora. Ďalej sa opisujú spôsoby prípravy tejto zlúčeniny, ktoré zahŕňajú a) spracovanie roztoku eletriptanu vo vode alebo v organickom rozpúšťadle obsahujúcom dostatočné množstvo vody umožňujúce tvorbu požadovaného monohydrátu s bromovodíkom alebo s jeho zdrojom alebo b) kryštalizáciou ktorejkoľvek inej formy eletriptan hydrobromidu alebo zmesí jeho foriem z vody alebo z organického rozpúšťadla obsahujúceho dostatočné množstvo vody umožňujúce tvorbu požadovaného monohydrátu; spôsob prípravy bezvodného eletriptan hydrobromidu dehydratáciou eletriptan hydrobromid monohydrátu.