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1. SG11202004910S - METHODS FOR ACTIVATING, MODIFYING AND EXPANDING GAMMA DELTA T CELLS FOR THE TREATMENT OF CANCER AND RELATED MALIGNANCIES

Office Singapour
Numéro de la demande 11202004910S
Date de la demande 26.11.2018
Numéro de publication 11202004910S
Date de publication 29.06.2020
Type de publication A1
CIB
C12N 5/0783
CCHIMIE; MÉTALLURGIE
12BIOCHIMIE; BIÈRE; SPIRITUEUX; VIN; VINAIGRE; MICROBIOLOGIE; ENZYMOLOGIE; TECHNIQUES DE MUTATION OU DE GÉNÉTIQUE
NMICRO-ORGANISMES OU ENZYMES; COMPOSITIONS LES CONTENANT; CULTURE OU CONSERVATION DE MICRO-ORGANISMES; TECHNIQUES DE MUTATION OU DE GÉNÉTIQUE; MILIEUX DE CULTURE
5Cellules non différenciées humaines, animales ou végétales, p.ex. lignées cellulaires; Tissus; Leur culture ou conservation; Milieux de culture à cet effet
07Cellules animales ou tissus animaux
071Cellules ou tissus de vertébrés, p.ex. cellules humaines ou tissus humains
078Cellules du sang ou du système immunitaire
0783Cellules T; Cellules NK; Progéniteurs de cellules T ou NK
CPC
A61K 31/663
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
663Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
A61K 31/675
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
675having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61K 38/2013
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins [IL]
2013IL-2
A61K 2035/122
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
122for inducing tolerance or supression of immune responses
A61K 2035/124
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
124the cells being hematopoietic, bone marrow derived or blood cells
Déposants IMMATICS US, INC.
Inventeurs DAO, Monique
MATA, Melinda
NOWICKA, Aleksandra
BULLIARD, Yannick
WALTER, Steffen
MISSEL, Sarah
KUTTRUFF-COQUI, Sabrina
HILF, Norbert
Données relatives à la priorité 10 2017 127 984.9 27.11.2017 DE
62/591,041 27.11.2017 US
Titre
(EN) METHODS FOR ACTIVATING, MODIFYING AND EXPANDING GAMMA DELTA T CELLS FOR THE TREATMENT OF CANCER AND RELATED MALIGNANCIES
Abrégé
(EN)
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau 11111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111 (43) International Publication Date 31 May 2019 (31.05.2019) (10) International Publication Number WO 2019/104269 Al WIPO I PCT (51) International Patent Classification: Cl2N 5/0783 (2010.01) (21) International Application Number: PCT/US2018/062442 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, 1E, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: 26 November 2018 (26.11.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/591,041 27 November 2017 (27.11.2017) US 10 2017 127 984.9 27 November 2017 (27.11.2017) DE (71) Applicant: IMMATICS US, INC. [US/US]; 2130 W. Hol- combe Blvd., Suite 900, Houston, TX 77030 (US). (72) Inventors: DAO, Monique; 2130 W. Holcombe Blvd., Suite 11. 3000, Houston, TX 77030 (US). MATA, Melin- da; 2130 W. Holcombe Blvd., Suite 11 .3000, Houston, TX 77030 (US). NOWICKA, Aleksandra; 2130 W. Hol- combe Blvd., Suite 11.3000, Houston, TX 77030 (US). BULLIARD, Yannick; 2130 W. Holcombe Blvd., Suite 11 .3000, Houston, TX 77030 (US). WALTER, Steffen; 2901 Wroxton Road, Houston, TX 77005 (US) MISSEL, Sarah; Franzosische Allee 13, Tubingen, 72072 (DE). KUTTRUFF-COQUI, Sabrina; TorstraBe 2-6, Filder- stadt-Sielmingen (DE). HILF, Norbert; Im Wengertacker 17, Kirchentellinsfurt (DE). (74) Agent: MCBEE, Susan E. Shaw; McBee Moore Wood- ward & Vanik IP, LLC, 510 South Market Street, Frederick, MD 21701 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, 41! ! Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (54) Title: METHODS FOR ACTIVATING, MODIFYING AND EXPANDING GAMMA DELTA T CELLS FOR THE TREAT- MENT OF CANCER AND RELATED MALIGNANCIES Nre © (57) Abstract: The present disclosure relates to expansion and activation of T cells. In an aspect, the present disclosure relates to expansion and activation of y6 T cells that may be used for transgene expression. In another aspect, the disclosure relates to expansion and activation of y6 T cells while depleting a- and/or 13-TCR positive cells. T cell populations comprising expanded y6 T cell and 11 O depleted or reduced a- and/or 13-TCR positive cells are also provided for by the instant disclosure. The disclosure further provides for eql methods of using the disclosed T cell populations.

Également publié en tant que
EP2018830327
JP2020546300
MXMX/a/2020/005503