Traitement en cours

Veuillez attendre...

Paramétrages

Paramétrages

Aller à Demande

1. RU02194038 - CARBOXAMIDE DERIVATIVES OF PYRROLIDINE OR PIPERIDINE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF INHIBITION OF PLATELET AGGREGATION

Office Fédération de Russie
Numéro de la demande 98121706/04
Date de la demande 29.04.1997
Numéro de publication 02194038
Date de publication 10.12.2002
Type de publication C2
CIB
7C 07D 211/60 A
7C 07D 401/06 B
7C 07D 401/12 B
7C 07D 401/14 B
7A 61K 31/445 B
7A 61K 31/4545 B
CPC
C07F 7/0812
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7Compounds containing elements of Groups 4 or 14 of the Periodic System
02Silicon compounds
08Compounds having one or more C—Si linkages
0803Compounds with Si-C or Si-Si linkages
081comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
0812comprising a heterocyclic ring
C07D 211/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
36with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 213/55
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24with substituted hydrocarbon radicals attached to ring carbon atoms
54Radicals substituted by carbon atoms having three bonds to heteroatoms, with at the most one to halogen, e.g. ester or nitrile radicals
55Acids; Esters
C07D 401/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
Déposants ORTO-MakNEJL FARMAS'JuTIKAL, INK. (US)
ОРТО-МакНЕЙЛ ФАРМАСЬЮТИКАЛ, ИНК. (US)
Inventeurs KOSTANTsO Majkl Dzh. (US)
КОСТАНЦО Майкл Дж. (US)
KhOEhKSTRA Uil'jam Dzh. (US)
ХОЭКСТРА Уильям Дж. (US)
MAR'JaNOFF Brjus E. (US)
МАРЬЯНОФФ Брюс Е. (US)
Mandataires Lebedeva Natal'ja Georgievna
Лебедева Наталья Георгиевна
Données relatives à la priorité 60/016,675 01.05.1996 US
Titre
(EN) CARBOXAMIDE DERIVATIVES OF PYRROLIDINE OR PIPERIDINE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF INHIBITION OF PLATELET AGGREGATION
(RU) КАРБОКСАМИДНЫЕ ПРОИЗВОДНЫЕ ПИРРОЛИДИНА ИЛИ ПИПЕРИДИНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ И СПОСОБ ИНГИБИРОВАНИЯ АГРЕГАЦИИ ТРОМБОЦИТОВ
Abrégé
(EN)
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of pyrrolidine or piperidine of the formula (I) , their enantiomers and pharmaceutically acceptable salts: where R10 means H or C(O)N(R1)YZ; R1 means H; Y means (CH2)p,(CH2)qCH(R3) or CH(R3)(CH2)q; R3 means aryl, aralkyl or heteroaryl; q = 1-3; p = 2 or 3; Z means CO2H, CO2-alkyl or 5-tetrazole; X means C(O); M means (CH2)m or piperidine-1-yl; m = 2; n = 2; R5 means H; A is taken among piperidine-2-yl, piperidine-3-yl, piperidine-4-yl of N-substituted piperidine. Compounds of the formula (I) inhibit aggregation of platelets and can be used in medicine. EFFECT: improved method of inhibition, valuable medicinal properties. 5 cl, 6 tbl

(RU)
Изобретение относится к новым производным пирролидина или пиперидина ф-лы (I), их энантиомерам и фармацевтически приемлемым солям где R10 - Н или C(O)N(R1)YZ, R1 - Н, Y - (СН2)р, (CH2)qCH(R3) или CH(R3)(CH2)q, R3 - арил, аралкил или гетероарил, q = 1-3, р = 2 или 3, Z - CO2H, СО2-алкил или 5-тетразол, Х-С(O), М-(СН2)n, или пиперидин-1-ил, m = 2, n = 2, R5 - Н, А выбирают из пиперидин-2-ила, пиперидин-3-ила, пиперидин-4-ила или N-замещенного пиперидина. Соединения ф-лы (I) ингибируют агрегацию тромбоцитов и могут найти применение в медицине. 3 с. и 2 з.п. ф-лы, 6 табл.

Autres publications associées