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1. PT860166 - APLICACAO DE NANOPARTICULAS A BASE DE POLIMEROS HIDROFILOS COMO FORMAS FARMACEUTICAS

Office
Portugal
Numéro de la demande 96932607
Date de la demande 22.10.1996
Numéro de publication 860166
Date de publication 29.04.2005
Type de publication E
CIB
A61K 9/51
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
9Préparations médicinales caractérisées par un aspect particulier
48Préparations en capsules, p.ex. de gélatine, de chocolat
50Microcapsules
51Nanocapsules
CPC
A61K 9/5161
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51Nanocapsules; Nanoparticles;
5107Excipients; Inactive ingredients
513Organic macromolecular compounds; Dendrimers
5161Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
Déposants ADVANCELL ADVANCED IN VITRO CE
Inventeurs JOSE ALONSO FERNANDEZ MARIA
PILAR CALVO SALVE
CARMEN REMUNAN LOPES
LUIS VILA JATO JOSE
Données relatives à la priorité 9601685 29.07.1996 ES
Titre
(PT) APLICACAO DE NANOPARTICULAS A BASE DE POLIMEROS HIDROFILOS COMO FORMAS FARMACEUTICAS
Abrégé
(EN) Application of nanoparticles based on hydrophilic polymers as, pharmaceutical forms for the administration of active macromolecules. The nanoparticles (having a nanometric size and a hydrophilic character), also called nanospheres or latex, are colloidal systems comprised of the combination of hydrophilic polymers and an active ingredient having a high molecular weight (active macromolecule, molecular weight higher than 1000 daltons). The hydrophilic polymers are the chitosane (an aminopolysaccharide) or its derivatives and the polyoxyethylene or its derivatives. The association of the active macromolecule to said nanoparticles takes place in an aqueous phase without having to use organic solvents or auxiliary toxic substances. The active ingredient charge capacity of the nanoparticles is extremely high and additionally said charge is released in a controlled and time extended way. Additionally, said nanoparticles have a positive surface electric charge which the intensity may vary in relation to its composition.