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1. MYPI 2020001371 - NOVEL PLATFORMS FOR CO-STIMULATION, NOVEL CAR DESIGNS AND OTHER ENHANCEMENTS FOR ADOPTIVE CELLULAR THERAPY

Office Malaisie
Numéro de la demande PI 2020001371
Date de la demande 27.09.2018
Numéro de publication PI 2020001371
Date de publication 27.03.2019
Type de publication A
CIB
A
ANÉCESSITÉS COURANTES DE LA VIE
C
CCHIMIE; MÉTALLURGIE
C
CCHIMIE; MÉTALLURGIE
C
CCHIMIE; MÉTALLURGIE
Déposants UNIVERSITY OF SOUTHERN CALIFORNIA
Inventeurs CHAUDHARY, Preet, M.
Mandataires SOO EE LIN
Données relatives à la priorité 62/564,249 27.09.2017 US
Titre
(EN) NOVEL PLATFORMS FOR CO-STIMULATION, NOVEL CAR DESIGNS AND OTHER ENHANCEMENTS FOR ADOPTIVE CELLULAR THERAPY
Abrégé
(EN)
THE DISCLOSURE PROVIDES COMPOSITIONS AND METHOD THAT PROMOTE ADOPTIVE CELLULAR THERAPY. THE DISCLOSURE PROVIDES POLYNUCLEOTIDES. VECTORS, SYSTEMS AND CELLS COMPRISING CHIMERIC ANTIGEN RECEPTORS (CARS), SYNTHETIC IMMUNE RECEPTORS (SIRS), AND THE LIKE IN COMBINATION THE SPECIFIC ACTIVATORS OF NFKB ACTIVITY, THUS IMPROVING CELLULAR PROLIFERATION, EXPRESSION AND REDUCED APOPTOSIS. WHICH IMPROVES CELL PERSISTENCE IN ADOPTIVE CELL THERAPY. (FIG. 2)