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1. IN1303/CHENP/2005 - INHIBITORS OF THE BINDING OF CHEMOKINES I-TAC OR SDF-1 TO THE CCXCKR2 RECEPTOR

Office
Inde
Numéro de la demande 1303/CHENP/2005
Date de la demande 17.07.2005
Numéro de publication 1303/CHENP/2005
Date de publication 10.08.2007
Numéro de délivrance 226698
Date de délivrance 13.02.2009
Type de publication B
CIB
C07D 20/09
Déposants CHEMOCENTRYX
Inventeurs MELIKIAN, Anita
BURNS, Jennifer
MCMASTER, Brian, E
SCHALL, Thomas
WRIGHT, J., J
Données relatives à la priorité 60/434,912 20.12.2002 US
60/516,151 30.10.2003 US
Titre
(EN) INHIBITORS OF THE BINDING OF CHEMOKINES I-TAC OR SDF-1 TO THE CCXCKR2 RECEPTOR
Abrégé
(EN)
Pharmaceutical compositions containing organic compounds of formula I or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Methods of interfering with SDF-1 and/or I-TAC binding to the CCXCKR2 receptor and treating cancer using the compounds and pharmaceutical compositions of the present invention are also disclosed.