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A process is disclosed for unstabilising viral quasi-species distributions and avoiding resistance phenomena by replicating the nucleic acids of the viruses belonging to the quasi-species distribution by means of a defective replication system. The defective replication system has a higher defective nucleotide integration rate than the viral wild type replication system and the viruses of the replication system having a higher defect integration rate are replicated at least as effectively as in the replication system of the virus wild type. The replication of the consensus sequence (nucleic acid sequence of the virus wild type) is negatively affected in relation to other replicable nucleic acids.