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1. CN102711713 - Method of inspection of sealed capsules with a process of determination of the quality of the seal and related equipment for in-line inspection

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Office
Chine
Numéro de la demande 201080061306.8
Date de la demande 01.11.2010
Numéro de publication 102711713
Date de publication 03.10.2012
Numéro de délivrance 102711713
Date de délivrance 25.02.2015
Type de publication B
CIB
G01N 33/15
GPHYSIQUE
01MÉTROLOGIE; TESTS
NRECHERCHE OU ANALYSE DES MATÉRIAUX PAR DÉTERMINATION DE LEURS PROPRIÉTÉS CHIMIQUES OU PHYSIQUES
33Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes G01N1/-G01N31/146
15Préparations médicinales
CPC
A61J 3/072
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
3Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
07into the form of capsules or similar small containers for oral use
071into the form of telescopically engaged two-piece capsules
072Sealing capsules, e.g. rendering them tamper-proof
G01N 22/04
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
22Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more
04Investigating moisture content
G01N 33/15
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
15Medicinal preparations ; ; Physical properties thereof, e.g. dissolubility
Déposants Capsugel Belgium NV
Inventeurs Herrmann Hans-Rainer
Huysmans Tom Regina Augustinus
Schlemm Udo
Mandataires yuan chaohui
Données relatives à la priorité 61/261002 13.11.2009 US
Titre
(EN) Method of inspection of sealed capsules with a process of determination of the quality of the seal and related equipment for in-line inspection
(ZH) 具有确定密封品质的过程的检查密封胶囊的方法以及用于在线检查的相关设备
Abrégé
(EN)
The invention relates to a method of inspection of a filled hard capsule sealed with a solvent sealing agent, including a process for determining the quality of the seal, said process comprising supplying a filled hard capsule (1) sealed with a solvent sealing agent; - supplying a microwave resonator (27) wherein a measuring field characterized by a resonance curve is generated; directing said capsule through the measuring field; measuring characteristics related to the modification of the resonance curve produced by the presence of the capsule (1 ) in the measuring field, in comparison with a reference resonance curve corresponding to an empty state of the resonator; and using the measured characteristics to determine a value associated with the quality of the seal. The invention also relates to a method for sorting capsules on the basis of the result of the inspection method and to associated equipment able to carry out such methods.

(ZH)

本发明涉及一种检查用溶解性密封剂密封的已填充硬胶囊的方法,包括用于确定密封品质的过程,所述过程包括:供应用溶解性密封剂(16)密封的已填充硬胶囊(1);供应微波谐振器(27),在所述微波谐振器内产生以谐振曲线为特征的测量场;将所述胶囊引导通过所述测量场;测量特性,所述特性与所述测量场内存在胶囊(1)时产生的谐振曲线相比较对应于所述谐振器的空状态的参考谐振曲线的修改有关;以及用测得的特性确定与密封品质相关联的值。本发明还涉及基于所述检查方法的结果来分拣胶囊的方法并且涉及能够执行此类方法的设备。