Traitement en cours

Veuillez attendre...

Paramétrages

Paramétrages

Aller à Demande

1. CN102026966 - Novel amino acid derivatives, method for preparing same, and therapeutic use thereof

Office Chine
Numéro de la demande 200980116831.2
Date de la demande 13.05.2009
Numéro de publication 102026966
Date de publication 20.04.2011
Numéro de délivrance 102026966
Date de délivrance 12.02.2014
Type de publication B
CIB
C07C 323/60
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
CCOMPOSÉS ACYCLIQUES OU CARBOCYCLIQUES
323Thiols, sulfures, hydropolysulfures ou polysulfures substitués par des halogènes, des atomes d'oxygène ou d'azote ou par des atomes de soufre ne faisant pas partie de groupes thio
50contenant des groupes thio et des groupes carboxyle liés au même squelette carboné
51ayant les atomes de soufre des groupes thio liés à des atomes de carbone acycliques du squelette carboné
60avec l'atome de carbone d'au moins un des groupes carboxyle lié à des atomes d'azote
C07C 323/65
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
CCOMPOSÉS ACYCLIQUES OU CARBOCYCLIQUES
323Thiols, sulfures, hydropolysulfures ou polysulfures substitués par des halogènes, des atomes d'oxygène ou d'azote ou par des atomes de soufre ne faisant pas partie de groupes thio
64contenant des groupes thio et des atomes de soufre, ne faisant pas partie de groupes thio, liés au même squelette carboné
65contenant des atomes de soufre de groupes sulfone ou sulfoxyde liés au squelette carboné
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
A61P 25/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
A61P 25/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
30for treating abuse or dependence
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
C07C 323/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
51having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
60with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Déposants 领先药物公司
Inventeurs M-C·富尼耶-扎武斯基
H·波拉斯
B·罗克
Mandataires 北京戈程知识产权代理有限公司 11314
Données relatives à la priorité 0853092 13.05.2008 FR
Titre
(EN) Novel amino acid derivatives, method for preparing same, and therapeutic use thereof
(ZH) 新型氨基酸衍生物、其制备方法和治疗用途
Abrégé
(EN)
The invention relates to novel compounds of the formula (I) R1NH-CH(R2)-CH2-S- S-CH2-C(R3)(R4)-CONH-C(R5)(R6)-COOR7, in which R1 is a (acyloxy)alkyl carbamate -C(O)-O-C(R8)(R9)-OC(O)-R10 group; R2 is a hydrocarbon chain, a methylene radical substituted by a heterocycle; R4 is a hydrogen atom and R3 is a phenyl or benzyl radical, a heteroaryl, a methylene group substituted by a heterocycle or R3 and R4 form together a saturated cycle; R5 and R6 are hydrogen, a hydrocarbon chain, a phenyl or benzyl radical or R5 and R6 form together a saturated cycle; R7 is hydrogen, a phenyl or benzyl radical, a group of the formula CR12(R13)C(O)OR14 or OCR12(R13)OC(O)R14 or OCR12(R13)OC(O)OR14. The invention also relates to the use of these compounds as a drug, and to a pharmaceutical composition containing said compounds and a pharmaceutically acceptable carrier. The invention further relates to the combined use of at least one cannabinoid derivative and/or morphine or one derivative thereof and/or Gaba derivatives for enhancing the analgesic and anti-depressive effect of the novel compounds of the formula (I).

(ZH)

本发明涉及新型通式(I)化合物R1NH-CH(R2)-CH2-S-S-CH2-C(R3)(R4)-CONH-C(R5)(R6)-COOR7,其中R1为(酰氧基)烷基氨基甲酸酯-C(O)-O-C(R8)(R9)-OC(O)-R10;R2为烃链、被杂环取代的亚甲基;R4为氢原子且R3为苯基或苄基、杂芳基、被杂环取代的亚甲基或R3和R4一起形成饱和环;R5和R6为氢、烃链、苯基或苄基或R5和R6一起形成饱和环;R7是氢、苯基或苄基、通式CR12(R13)C(O)OR14或OCR12(R13)OC(O)R14或OCR12(R13)OC(O)OR14的基团。本发明还涉及这些化合物作为药物的用途,含有所述化合物和药学上可接受的载体的药物组合物。本发明进一步涉及至少一种大麻类衍生物和/或吗啡或其一种衍生物和/或γ-氨基丁酸衍生物用于增强新型通式(I)化合物的止痛和抗抑郁作用的联合应用。