(EN)
Methods for preparing complex multivalent immunogenic conjugates that includ simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction involves reaction of a hydrazide group on one reactant with an aldehyde or cyanat ester group on the other reactant.
(ZH)
本发明提供了制备复合的多价免疫原性结合物的方法,包括将多种免疫原性不同的多糖与至少一种蛋白同时进行反应,以制备复合的多价免疫原性结合物。该同时进行的反应包括一种反应物上的酰肼基团与另一种反应物上的醛或氰酸酯基团的反应。