CN101405028 Methods for preparing complex multivalent immunogenic conjugates

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Numéro de la demande 200780009505.2

Date de la demande 16.03.2007

Numéro de publication 101405028

Date de publication 08.04.2009

Numéro de délivrance 101405028

Date de délivrance 19.08.2015

Type de publication B

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Déposants 美国政府健康及人类服务部

Inventeurs 澈黄·罗伯特·李

Mandataires 中原信达知识产权代理有限责任公司 11219
中原信达知识产权代理有限责任公司 11219

Données relatives à la priorité 60/783,490 17.03.2006 US

Titre

(EN) Methods for preparing complex multivalent immunogenic conjugates

(ZH) 制备复合的多价免疫原性结合物的方法

Abrégé

(EN)

Methods for preparing complex multivalent immunogenic conjugates that includ simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction involves reaction of a hydrazide group on one reactant with an aldehyde or cyanat ester group on the other reactant.

(ZH)

本发明提供了制备复合的多价免疫原性结合物的方法，包括将多种免疫原性不同的多糖与至少一种蛋白同时进行反应，以制备复合的多价免疫原性结合物。该同时进行的反应包括一种反应物上的酰肼基团与另一种反应物上的醛或氰酸酯基团的反应。

Également publié en tant que

US12283894

BRPI0708849

EP1993604

CA2644724

KR1020130135399

EP3006041

KR1020160038086

AU2007227504

KR1020170024141

IDW00200802974

KR1020180028558

WO/2007/109129

IN3682/KOLNP/2008

IDIDW00200802974

KR1020080103604

KR1020157006038

A	NÉCESSITÉS COURANTES DE LA VIE
61	SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
K	PRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
39	Préparations médicinales contenant des antigènes ou des anticorps
385	Haptènes ou antigènes, liés à des supports

A	NÉCESSITÉS COURANTES DE LA VIE
61	SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
K	PRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
39	Préparations médicinales contenant des antigènes ou des anticorps
02	Antigènes bactériens
08	Clostridium, p.ex. Clostridium tetani

A	NÉCESSITÉS COURANTES DE LA VIE
61	SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
K	PRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
39	Préparations médicinales contenant des antigènes ou des anticorps
02	Antigènes bactériens
095	Neisseria

A	NÉCESSITÉS COURANTES DE LA VIE
61	SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
K	PRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
39	Préparations médicinales contenant des antigènes ou des anticorps
385	Haptènes ou antigènes, liés à des supports

A	NÉCESSITÉS COURANTES DE LA VIE
61	SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
K	PRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
39	Préparations médicinales contenant des antigènes ou des anticorps
02	Antigènes bactériens
08	Clostridium, p.ex. Clostridium tetani

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1. CN101405028 - Methods for preparing complex multivalent immunogenic conjugates

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A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
385	Haptens or antigens, bound to carriers

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31	Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04	Antibacterial agents

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
1	General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
06	using protecting groups or activating agents
08	using activating agents
084	containing nitrogen

Y	SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02	TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
A	TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50	in human health protection, e.g. against extreme weather
30	Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid
64	Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
6415	Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid
64	Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
646	the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid
64	Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
6415	Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid
64	Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
646	the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines