(EN)
The invention relates to a polypeptide wherein at least one of the amino, carboxyl, mercapto or guanidino group in a polypeptide molecule having human granulocyte colony stimulating factor activity is chemically modified by a chemical modifying agent, and a platelet production promoter comprising said polypeptide, a method for treating a patient with decreased platelet counts comprising administering an effective amount of said polypeptide to the patient, the use of said polypeptide for the production of pharmaceutical compositions which are useful for the treatment of the patient with decreased platelet counts, and the compositions for treating the patient with decreased platelet counts, which comprises an effective dose of said polypeptide in a pharmaceutically acceptable dosage form with a pharmaceutical acceptable carrier.
(ZH) 本发明是关于一种多肽，其中在一个具有人粒性白细胞集落刺激因子活性的多肽分子中，至少有氨基、羧基、巯基、或胍基之一被一种化学修饰剂所修饰，本发明还涉及到一种含有该种多肽的血小板生成促进剂，一种包括给予病人用一个有效剂量的该种多肽来治疗血小板数量减少的病人的方法，以及将该种多肽用于生产治疗血小板数量减少的病人有用的药物成分，还涉及到一个治疗血小板数量减少的病人的药物组方，此组方由一个此种多肽的有效剂量，以及药剂学合适的剂型，与药物可接受的载体共同组成。
