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1. CN109369372 - Method for preparing 3- hydroxybutyrate

Office Chine
Numéro de la demande 201811432860.7
Date de la demande 28.11.2018
Numéro de publication 109369372
Date de publication 22.02.2019
Type de publication A
CIB
C07C 51/41
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
CCOMPOSÉS ACYCLIQUES OU CARBOCYCLIQUES
51Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides
41Préparation de sels d'acides carboxyliques par conversion de ces acides ou de leurs sels en sels ayant la même partie acide carboxylique
C07C 59/01
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
CCOMPOSÉS ACYCLIQUES OU CARBOCYCLIQUES
59Composés comportant des groupes carboxyle liés à des atomes de carbone acycliques et contenant l'un des groupes OH, O-métal, -CHO, cétone, éther, des groupes , des groupes ou des groupes
01Composés saturés ne comportant qu'un groupe carboxyle et contenant des groupes hydroxyle ou O-métal
CPC
C07C 51/09
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
51Preparation of carboxylic acids or their salts, halides or anhydrides
09from carboxylic acid esters or lactones
C07C 51/412
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
51Preparation of carboxylic acids or their salts, halides or anhydrides
41Preparation of salts of carboxylic acids
412by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
C07C 51/43
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
51Preparation of carboxylic acids or their salts, halides or anhydrides
42Separation; Purification; Stabilisation; Use of additives
43by change of the physical state, e.g. crystallisation
B01J 23/04
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
23Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
02of the alkali- or alkaline earth metals or beryllium
04Alkali metals
C07C 51/44
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
51Preparation of carboxylic acids or their salts, halides or anhydrides
42Separation; Purification; Stabilisation; Use of additives
43by change of the physical state, e.g. crystallisation
44by distillation
C07C 59/01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
01Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
Déposants SHANGHAI SHINE HIGH INTERNATIONAL TRADE CO., LTD.
上海欣海国际贸易有限公司
Inventeurs HUYAN WANG
呼延旺
Mandataires 上海翰信知识产权代理事务所(普通合伙) 31270
Titre
(EN) Method for preparing 3- hydroxybutyrate
(ZH) 一种制备3-羟基丁酸盐的方法
Abrégé
(EN)
The invention discloses a method for preparing 3-hydroxybutyrate. The method comprises the steps that (1) 3-ethyl hydroxybutyrate or 3-methyl hydroxybutyrate is provided and is hydrolyzed through a base catalyst to obtain 3-hydroxybutyric acid; and (2) the 3-hydroxybutyric acid reacts with an inorganic base to obtain the 3- hydroxybutyrate. Through the method, an aquatic salt forming mode is adopted, reacting is more complete, the reaction time is saved, energy consumption and material losses are lowered, the product yield is improved, and the production cost is saved. The concentration process in preparation of 3-hydroxybutyrate crude products is omitted, the series of processes of refining concentration of anhydrous ethanol, adding of acetone for crystallization, filtering, washing, drying and the like in preparing of 3-hydroxybutyrate finished products are omitted, an organic solvent, namely, acetone is omitted, material losses and energy consumption for the corresponding processesare reduced, and the production cost of the 3-hydroxybutyrate is greatly lowered. The heating process in roughing and refining of the 3-hydroxybutyrate is reduced, the problem that the 3-hydroxybutyrate finished products are easily affected with damp is also solved through the aquatic salt forming mode, and the quality of the 3-hydroxybutyrate is guaranteed.

(ZH)
本发明揭示了一种3‑羟基丁酸盐的制备方法,包括:(1)提供3‑羟基丁酸乙酯或3‑羟基丁酸甲酯,经碱性催化剂水解,得3‑羟基丁酸;(2)3‑羟基丁酸与无机碱反应,得到3‑羟基丁酸盐。本发明采用水中成盐,使反应进行的更彻底,节省了反应时间,降低了能耗及物料损失,提高了产品收率,节约了生产成本。省略了3‑羟基丁酸盐粗品制备的浓缩过程,以及3‑羟基丁酸盐成品的无水乙醇精制浓缩、加丙酮析晶、过滤、洗涤、干燥等一系列过程,省去了有机溶剂丙酮,而且节约了相应过程的物料损失和能源消耗,大幅度降低了3‑羟基丁酸成盐的生产成本。减少了3‑羟基丁酸盐的粗制及精制中的受热过程,水中成盐也避免了3‑羟基丁酸盐成品易吸潮的问题,保证了3‑羟基丁酸成盐的质量。

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