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1. CA2113272 - METHODE DE TRAITEMENT DU SIDA PAR L'AMPHOTERICINE B A TOXICITE REDUITE

Office
Canada
Numéro de la demande 2113272
Date de la demande 12.08.1992
Numéro de publication 2113272
Date de publication 04.03.1993
Type de publication A1
CIB
A61K 9/51
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
9Préparations médicinales caractérisées par un aspect particulier
48Préparations en capsules, p.ex. de gélatine, de chocolat
50Microcapsules
51Nanocapsules
A61K 9/16
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
9Préparations médicinales caractérisées par un aspect particulier
14à l'état particulaire, p.ex. poudres
16Agglomérés; Granulés; Microbilles
CPC
A61K 9/5115
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51Nanocapsules; Nanoparticles;
5107Excipients; Inactive ingredients
5115Inorganic compounds
A61K 9/1617
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1617Organic compounds, e.g. phospholipids, fats
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
Inventeurs MARTIN, FRANCIS J.
WOODLE, MARTIN C.
GUO, LUKE S. S.
Données relatives à la priorité 744,915 14.08.1991 US
Titre
(EN) HIV-TREATMENT METHOD WITH LOW-TOXICITY AMPHOTERICIN B
(FR) METHODE DE TRAITEMENT DU SIDA PAR L'AMPHOTERICINE B A TOXICITE REDUITE
Abrégé
(EN) 2113272 9303737 PCTABS00020 A method of inhibiting HIV infection in peripheral blood macrophages, as evidenced by an inhibition of HIV p24 antigen expression in the infected cells. The method includes exposing the infected macrophages to a composition containing particles of amphotericin B:cholesteryl sulfate, molar ratio 1:0.5 to 1:4, at a concentration of at least about 0.01 µM amphotericin B.


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