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1. AU2004200091 - Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use

Office Australie
Numéro de la demande 2004200091
Date de la demande 09.01.2004
Numéro de publication 2004200091
Date de publication 22.01.2004
Type de publication B2
CIB
A61K 31/381
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
31Préparations médicinales contenant des ingrédients actifs organiques 
33Composés hétérocycliques
38ayant le soufre comme hétéro-atome d'un cycle
381ayant des cycles à cinq chaînons
Déposants Nicox S.A.
Inventeurs Bandarage, Upul K
Dong, Qing
Fang, Xinqin
Garvey, David S
Mercer, Gregory J
Richardson, Stewart K
Schroeder, Joseph D
Wang, Tiansheng
Mandataires Maxwells Patent & Trade Mark Attorneys Pty Ltd
Données relatives à la priorité 09/182433 30.10.1998 US
Titre
(EN) Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
Abrégé
(EN)
The present invention describes novel nitrosated and or nitrosylated nonsteroidal antiinflammatory drugs, and novel compositions comprising at least one nitrosated and or nitrosylated nonsteroidal intiinflammatory drug, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory compounds; treating and or preventing gastrointestinal disorders; treating infoammatory disease states and disorders; and treating and 'or preventing ophthalmic diseases or disorders