(EN) The present invention describes novel nitrosated and or nitrosylated nonsteroidal antiinflammatory drugs, and novel compositions comprising at least one nitrosated and or nitrosylated nonsteroidal intiinflammatory drug, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory compounds; treating and or preventing gastrointestinal disorders; treating infoammatory disease states and disorders; and treating and 'or preventing ophthalmic diseases or disorders