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1. AU2001039534 - Single chain class I major histo-compatibility complexes, constructs encoding same and methods of generating same

Note: Texte fondé sur des processus automatiques de reconnaissance optique de caractères. Seule la version PDF a une valeur juridique

[ EN ]
The claims defining the invention are as follows:
1. A multimeric MHC class I complex comprising a plurality of recombinant polypeptide monomers each including a functional human 3-2 microglobulin covalently linked upstream of a functional human MHC class I heavy chain.
2. The multimeric MHC class I complex of claim 1, wherein said plurality of recombinant polypeptide monomers are linked to a common substrate.
3. A plurality of complexes, each being composed of an antigenic peptide being capable of binding a human MHC class I, and a chimeric polypeptide which comprises a functional human 3-2 microglobulin translationally fused upstream of a functional human MHC class I heavy chain, wherein all of said plurality of complexes are recognizable by one CTL clone.
4. The plurality of complexes of claim 3, wherein said chimeric polypeptide further comprises a linker peptide being interposed between said functional human 3-2 microglobulin and said functional human MHC class I heavy chain.
5. The plurality of complexes of claim 3, wherein said antigenic peptide is covalently linked to said chimeric polypeptide.
6. A multimeric MHC class I-peptide complex comprising at least 2 complexes of the plurality of complexes of claim 3.
Dated:      3  August     2007