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1. AU1998079332 - Heat shock factor activity inhibitors

Office
Australie
Numéro de la demande 79332/98
Date de la demande 25.06.1998
Numéro de publication 1998079332
Date de publication 11.03.1999
Type de publication A
CIB
C07D 405/06
CCHIMIE; MÉTALLURGIE
07CHIMIE ORGANIQUE
DCOMPOSÉS HÉTÉROCYCLIQUES
405Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle
02contenant deux hétérocycles
06liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
CPC
C07D 405/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Déposants Kaneka Corporation
Inventeurs Fuse, Yoshihide
Kitahara, Mikio
Morikawa, Souichi
Yamamoto, Kozo
Yokota, Shinichi
Données relatives à la priorité 9-171321 27.06.1997 JP
Titre
(EN) Heat shock factor activity inhibitors
Abrégé
(EN) Remedies for diseases which function by regulating the expression of a protein induced by a heat shock factor (HSF). Specifically, HSF activity inhibitors or agents inhibiting the induction of the production of a protein regulated by HSF, wherein novel benzo-1,3-dioxole compounds represented by general formula (I) inhibit the transcription of a structural gene having a heat shock element sequence, which is a transcriptional regulatory factor, in a gene region participating in the transcription into RNA, thus inhibit the translation of this gene into a protein and, in its turn, suppress the induction of the production of the RNA, protein, etc. encoded by the gene; and remedies and preventives usable in thermotherapy for cancer and remedies and preventives for stress-induced diseases such as depression. Compounds represented by general formula (I): wherein X is -CH2- and R1 represents C1-2 alkyl, formyl or halogeno; or X is -(CH2)2- and R1 represents C1-3 alkyl, formyl, acetyl, hydrogen or halogeno.