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1. AU1997039810 - Controlled release microparticles with a hydrophobic material

Office
Australie
Numéro de la demande 39810/97
Date de la demande 14.08.1997
Numéro de publication 1997039810
Date de publication 07.05.1998
Type de publication A
CIB
A61K 9/16
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
9Préparations médicinales caractérisées par un aspect particulier
14à l'état particulaire, p.ex. poudres
16Agglomérés; Granulés; Microbilles
CPC
A61K 9/1647
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1641obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
1647Polyesters, e.g. poly(lactide-co-glycolide)
A61K 9/1617
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1617Organic compounds, e.g. phospholipids, fats
Déposants Alkermes Controlled Therapeutics, Inc.
Inventeurs Urian, R. Craig
Zhang, Yan
Données relatives à la priorité 08701229 21.08.1996 US
Titre
(EN) Controlled release microparticles with a hydrophobic material
Abrégé
(EN) A pharmaceutical composition and a method of forming said composition for the sustained release of biologically active agent. The pharmaceutical composition of the invention comprises (a) a sustained release delivery device consisting essentially of (i) a drug delivery device having a biologically active agent disposed within said device and characterized by a plurality of interior spaces, and (ii) a hydrophobic material wherein said material is contained within a substantial number of interior spaces of the drug delivery device as to have a beneficial effect and (b) a pharmaceutical carrier. Alternatively, the pharmaceutical composition of the invention is in the substantial absence of a pharmaceutical carrier. The method of the invention includes imbibing the interior spaces of the drug delivery device with a hydrophobic material and removing the hydrophobic material from the exterior surface, thereby obtaining a pharmaceutical composition with a significantly reduced initial burst.
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