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1. CN107148265 - Surfactant-stripped micelle compositions with high cargo to surfactant ratio

Office Chine
Numéro de la demande 112015000046842
Date de la demande 02.07.2015
Numéro de publication 107148265
Date de publication 08.09.2017
Numéro de délivrance 107148265
Date de délivrance 05.04.2019
Type de publication B
CIB
A61K 9/107
ANÉCESSITÉS COURANTES DE LA VIE
61SCIENCES MÉDICALE OU VÉTÉRINAIRE; HYGIÈNE
KPRÉPARATIONS À USAGE MÉDICAL, DENTAIRE OU POUR LA TOILETTE
9Préparations médicinales caractérisées par un aspect particulier
10Dispersions; Emulsions
107Emulsions
CPC
A61K 9/1075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions ; ; Emulsion preconcentrates; Micelles
1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
A61K 31/01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
01Hydrocarbons
A61K 31/07
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
07Retinol compounds, e.g. vitamin A
A61K 31/122
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
122having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 31/23
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
23of acids having a carboxyl group bound to a chain of seven or more carbon atoms
A61K 31/232
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
23of acids having a carboxyl group bound to a chain of seven or more carbon atoms
232having three or more double bonds, e.g. etretinate
Déposants THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
纽约州立大学研究基金会
Inventeurs LOVELL JONATHAN
乔纳森·罗维尔
ZHANG YUMIAO
张育淼
SONG WENTAO
宋文涛
GENG JUMIN
耿具民
KIM CHULHONG
金哲弘
JEON MANSIK
全晚植
Mandataires 北京清亦华知识产权代理事务所(普通合伙) 11201
Données relatives à la priorité 62/020,233 02.07.2014 US
62/020,249 02.07.2014 US
Titre
(EN) Surfactant-stripped micelle compositions with high cargo to surfactant ratio
(ZH) 具有高的负载物与表面活性剂比率的剥离了表面活性剂的胶束组合物
Abrégé
(EN)
Provided are compositions and methods relating to hydrophobic agent loaded-micelle. The micelles comprise surfactant (such as poloxamer) and have hydrophobic agents incorporated therein. The compositions substantially lack surfactant that is not associated with the micelles. The compositions are able to achieve high hydrophobic agent: surfactant molar ratio. The compositions can be used for drug delivery and imaging applications.

(ZH)
本发明提供了与负载疏水剂的胶束相关的组合物和方法。所述胶束包含表面活性剂(例如泊洛沙姆)并且具有掺入其中的疏水剂。所述组合物基本上不含与胶束不相关的表面活性剂。所述组合物能够实现高疏水剂:表面活性剂摩尔比。所述组合物可用于药物递送和成像应用。